Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

Literature DB >> 10200246

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

Abstract

The most recently discovered PTEN tumor suppressor gene has been found to be defective in a large number of human cancers. In addition, germ-line mutations in PTEN result in the dominantly inherited disease Cowden syndrome, which is characterized by multiple hamartomas and a high proclivity for developing cancer. A series of publications over the past year now suggest a mechanism by which PTEN loss of function results in tumors. PTEN appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell growth and survival by dephosphorylating the 3 position of phosphoinositides.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1999 PMID： 10200246 PMCID： PMC33561 DOI： 10.1073/pnas.96.8.4240

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

76 in total

1. PTEN: sometimes taking it off can be better than putting it on.

Authors: M P Myers; N K Tonks
Journal: Am J Hum Genet Date: 1997-12 Impact factor: 11.025

2. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.

Authors: D J Marsh; V Coulon; K L Lunetta; P Rocca-Serra; P L Dahia; Z Zheng; D Liaw; S Caron; B Duboué; A Y Lin; A L Richardson; J M Bonnetblanc; J M Bressieux; A Cabarrot-Moreau; A Chompret; L Demange; R A Eeles; A M Yahanda; E R Fearon; J P Fricker; R J Gorlin; S V Hodgson; S Huson; D Lacombe; C Eng
Journal: Hum Mol Genet Date: 1998-03 Impact factor: 6.150

3. A study of the PTEN/MMAC1 gene in 136 breast cancer families.

Authors: J Chen; P Lindblom; A Lindblom
Journal: Hum Genet Date: 1998-01 Impact factor: 4.132

4. Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.

Authors: K Okami; L Wu; G Riggins; P Cairns; M Goggins; E Evron; N Halachmi; S A Ahrendt; A L Reed; W Hilgers; S E Kern; W M Koch; D Sidransky; J Jen
Journal: Cancer Res Date: 1998-02-01 Impact factor: 12.701

5. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.

Authors: H Suzuki; D Freije; D R Nusskern; K Okami; P Cairns; D Sidransky; W B Isaacs; G S Bova
Journal: Cancer Res Date: 1998-01-15 Impact factor: 12.701

6. Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation.

Authors: D J Marsh; P L Dahia; V Coulon; Z Zheng; F Dorion-Bonnet; K M Call; R Little; A Y Lin; R A Eeles; A M Goldstein; S V Hodgson; A L Richardson; B G Robinson; H C Weber; M Longy; C Eng
Journal: Genes Chromosomes Cancer Date: 1998-01 Impact factor: 5.006

7. PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.

Authors: W Liu; C D James; L Frederick; B E Alderete; R B Jenkins
Journal: Cancer Res Date: 1997-12-01 Impact factor: 12.701

8. Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.

Authors: J Boström; J M Cobbers; M Wolter; G Tabatabai; R G Weber; P Lichter; V P Collins; G Reifenberger
Journal: Cancer Res Date: 1998-01-01 Impact factor: 12.701

9. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.

Authors: A Hemminki; D Markie; I Tomlinson; E Avizienyte; S Roth; A Loukola; G Bignell; W Warren; M Aminoff; P Höglund; H Järvinen; P Kristo; K Pelin; M Ridanpää; R Salovaara; T Toro; W Bodmer; S Olschwang; A S Olsen; M R Stratton; A de la Chapelle; L A Aaltonen
Journal: Nature Date: 1998-01-08 Impact factor: 49.962

10. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.

Authors: D E Jenne; H Reimann; J Nezu; W Friedel; S Loff; R Jeschke; O Müller; W Back; M Zimmer
Journal: Nat Genet Date: 1998-01 Impact factor: 38.330

569 in total

Review 1. Apoptosis and cancer drug targeting.

Authors: W R Sellers; D E Fisher
Journal: J Clin Invest Date: 1999-12 Impact factor: 14.808

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

1. PTEN: sometimes taking it off can be better than putting it on.

2. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.

3. A study of the PTEN/MMAC1 gene in 136 breast cancer families.

4. Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.

5. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.

6. Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation.

7. PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.

8. Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.

9. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.

10. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.

Review 1. Apoptosis and cancer drug targeting.

2. Phosphorylation of the PTEN tail regulates protein stability and function.

3. Protein phosphorylation and protein phosphatases. De Panne, Belgium, September 19-24, 1999.

4. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

5. Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1.

6. Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein.

Review 7. Expression patterns of cellular growth-controlling genes in non-medullary thyroid cancer: basic aspects.

8. Region-specific transcriptional response to chronic nicotine in rat brain.

Review 9. AKT plays a central role in tumorigenesis.

10. SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation.