Literature DB >> 10197751

Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum.

F Shamsa1, A Ahmadiani, R Khosrokhavar.   

Abstract

Barberry (Berberis vulgaris) is a well known medicinal plant in Iran and has also been used as food. The antihistaminic and anticholinergic activity of aqueous extract of barberry fruits were investigated on isolated guinea-pig ileum, and dose response curves of histamine and acetylcholine with and without extract were plotted. The pA2 values for antihistaminic activity of extract and dexchlorpheniramine were calculated (extract; pA2 +/- S.E.M. = 4.50 +/- 0.01[-log C (g/l)]; dexchlorpheniramine; pA2 +/- S.E.M. = 9.36 +/- 0.14[-log C (M)]) and compared with each other. The pA2 values for anticholinergic activity of extract and atropine were also calculated (extract, pA2 +/- S.E.M. = 4.37 +/- 0.03[-log C (g/l)]; atropine, pA2 +/- S.E.M. = 8.99 +/- 0.13[-log C (M)]) and compared. The results indicated antihistaminic and anticholinergic activity of extract that seems to be of the competitive type.

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Year:  1999        PMID： 10197751     DOI： 10.1016/s0378-8741(98)00122-6

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  21 in total

1.  Binding of berberine to bovine serum albumin: spectroscopic approach.

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2.  Comparison of the Effects of Myrtus Communis L, Berberis Vulgaris and Metronidazole Vaginal Gel alone for the Treatment of Bacterial Vaginosis.

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Review 4.  Phytochemistry and pharmacology of berberis species.

Authors:  Najmeh Mokhber-Dezfuli; Soodabeh Saeidnia; Ahmad Reza Gohari; Mahdieh Kurepaz-Mahmoodabadi
Journal:  Pharmacogn Rev       Date:  2014-01

5.  New aspects of Saccharomyces cerevisiae as a novel carrier for berberine.

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Journal:  Daru       Date:  2013-12-20       Impact factor: 3.117

6.  In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects.

Authors:  Abeer E Abd El-Wahab; Doaa A Ghareeb; Eman E M Sarhan; Marwa M Abu-Serie; Maha A El Demellawy
Journal:  BMC Complement Altern Med       Date:  2013-09-05       Impact factor: 3.659

7.  Synthesis and antihistaminic activity of 3H-benzo [4,5] thieno [2,3-d][1,2,3] triazin-4-ones.

Authors:  Gollapalle L Viswanatha; B Janaki Priyadarshini; Nandakumar Krishnadas; Saravanan Janardhanan; Srinath Rangappa; Shylaja Hanumanthappa
Journal:  Saudi Pharm J       Date:  2011-05-24       Impact factor: 4.330

Review 8.  A review on biological and chemical diversity in Berberis (Berberidaceae).

Authors:  Sharad Srivastava; Manjoosha Srivastava; Ankita Misra; Garima Pandey; Aks Rawat
Journal:  EXCLI J       Date:  2015-02-20       Impact factor: 4.068

9.  In vitro antioxidant effects of barberry fruit extracts.

Authors:  Durdi Qujeq; Solmaz Kamei
Journal:  Int J Mol Cell Med       Date:  2012

10.  Comparative Study of Berberis vulgaris Fruit Extract and Berberine Chloride Effects on Acetic Acid-Induced Colitis in Rats.

Authors:  Mohsen Minaiyan; Alireza Ghannadi; Parvin Mahzouni; Elham Jaffari-Shirazi
Journal:  Iran J Pharm Res       Date:  2011       Impact factor: 1.696
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