| Literature DB >> 10197537 |
R Grailhe1, C Waeber, S C Dulawa, J P Hornung, X Zhuang, D Brunner, M A Geyer, R Hen.
Abstract
In order to determine the distribution and function of the 5-HT5A serotonin receptor subtype, we generated knockout mice lacking the 5-HT5A gene. Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory bulb, neocortex, and medial habenula. When exposed to novel environments, the 5A-KO mice displayed increased exploratory activity but no change in anxiety-related behaviors. In addition, the stimulatory effect of LSD on exploratory activity was attenuated in 5A-KO mice. These results suggest that 5-HT5A receptors modulate the activity of neural circuits involved specifically in exploratory behavior and suggest that some of the psychotropic effects of LSD may be mediated by 5-HT5A receptors.Entities:
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Year: 1999 PMID： 10197537 DOI： 10.1016/s0896-6273(00)80712-6
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173