Literature DB >> 10196768

Actinorhodin production by Streptomyces coelicolor A3(2) in iron-restricted media.

S Coisne1, M Béchet, R Blondeau.   

Abstract

Production of the polyketide antibiotic actinorhodin by Streptomyces coelicolor A3(2) was investigated using a defined medium with or without iron supplementation. Iron limitation was found to enhance the intracellular production and export of the pigmented antibiotic. The effect of iron deficiency was particularly pronounced when the bacterium was grown with nitrate instead of ammonium. Analysis of the excreted pigment led to the identification of the lactone form of actinorhodin, gamma-actinorhodin.

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Year:  1999        PMID： 10196768     DOI： 10.1046/j.1365-2672.1999.00509.x

Source DB:  PubMed          Journal:  Lett Appl Microbiol        ISSN： 0266-8254            Impact factor:   2.858


  13 in total

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