Literature DB >> 10195638

Size fractionation of bacterial capsular polysaccharides for their use in conjugate vaccines.

P Costantino1, F Norelli, A Giannozzi, S D'Ascenzi, A Bartoloni, S Kaur, D Tang, R Seid, S Viti, R Paffetti, M Bigio, C Pennatini, G Averani, V Guarnieri, E Gallo, N Ravenscroft, C Lazzeroni, R Rappuoli, C Ceccarini.   

Abstract

We have developed a chromatographic method suitable for the fractionation of polysaccharides having a negatively charged group. The method permits the removal of all those polysaccharide fragments having a short sequence and which are likely unsuitable for conjugate vaccine construction. The selected polysaccharide fragments can be used to produce glycoconjugate vaccines containing a restricted saccharide polydispersion. We have applied this chromatographic method to three different antigens, Haemophilus influenzae type b and Neisseria meningitidis group A and group C polysaccharides. The method is easily adapted for manufacturing purposes.

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Year:  1999        PMID： 10195638     DOI： 10.1016/s0264-410x(98)00348-x

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  15 in total

1.  N19 polyepitope as a carrier for enhanced immunogenicity and protective efficacy of meningococcal conjugate vaccines.

Authors:  Karin Baraldo; Elena Mori; Antonella Bartoloni; Roberto Petracca; Aldo Giannozzi; Francesco Norelli; Rino Rappuoli; Guido Grandi; Giuseppe Del Giudice
Journal:  Infect Immun       Date:  2004-08       Impact factor: 3.441

2.  Combined conjugate vaccines: enhanced immunogenicity with the N19 polyepitope as a carrier protein.

Authors:  Karin Baraldo; Elena Mori; Antonella Bartoloni; Francesco Norelli; Guido Grandi; Rino Rappuoli; Oretta Finco; Giuseppe Del Giudice
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

3.  Investigating the immunodominance of carbohydrate antigens in a bivalent unimolecular glycoconjugate vaccine against serogroup A and C meningococcal disease.

Authors:  Roberto Adamo; Alberto Nilo; Carole Harfouche; Barbara Brogioni; Simone Pecetta; Giulia Brogioni; Evita Balducci; Vittoria Pinto; Sara Filippini; Elena Mori; Marta Tontini; Maria Rosaria Romano; Paolo Costantino; Francesco Berti
Journal:  Glycoconj J       Date:  2014-09-26       Impact factor: 2.916

4.  Epitopes recognized by a nonautoreactive murine anti-N-propionyl meningococcal group B polysaccharide monoclonal antibody.

Authors:  Gregory R Moe; Apurva Dave; Dan M Granoff
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

5.  Immunogenicity in a mouse model of a conjugate vaccine made with a synthetic single repeating unit of type 14 pneumococcal polysaccharide coupled to CRM197.

Authors:  Fatme Mawas; Jutta Niggemann; Christopher Jones; Michael J Corbel; Johannis P Kamerling; Johannes F G Vliegenthart
Journal:  Infect Immun       Date:  2002-09       Impact factor: 3.441

6.  Water accessibility, aggregation, and motional features of polysaccharide-protein conjugate vaccines.

Authors:  Francesco Berti; Paolo Costantino; Marco Fragai; Claudio Luchinat
Journal:  Biophys J       Date:  2004-01       Impact factor: 4.033

Review 7.  Designing vaccines for the twenty-first century society.

Authors:  Oretta Finco; Rino Rappuoli
Journal:  Front Immunol       Date:  2014-01-23       Impact factor: 7.561

Review 8.  Potential targets for next generation antimicrobial glycoconjugate vaccines.

Authors:  Francesca Micoli; Paolo Costantino; Roberto Adamo
Journal:  FEMS Microbiol Rev       Date:  2018-05-01       Impact factor: 16.408

9.  A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A.

Authors:  Jacopo Enotarpi; Marta Tontini; Cristiana Balocchi; Daan van der Es; Ludovic Auberger; Evita Balducci; Filippo Carboni; Daniela Proietti; Daniele Casini; Dmitri V Filippov; Hermen S Overkleeft; Gijsbert A van der Marel; Cinzia Colombo; Maria Rosaria Romano; Francesco Berti; Paolo Costantino; Jeroen D C Codeé; Luigi Lay; Roberto Adamo
Journal:  Nat Commun       Date:  2020-09-07       Impact factor: 14.919

10.  Selectively Charged and Zwitterionic Analogues of the Smallest Immunogenic Structure of Streptococcus Pneumoniae Type 14.

Authors:  Tiziana Gragnani; Doretta Cuffaro; Silvia Fallarini; Grazia Lombardi; Felicia D'Andrea; Lorenzo Guazzelli
Journal:  Molecules       Date:  2019-09-19       Impact factor: 4.411
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