| Literature DB >> 10195488 |
R J Roberge1, K H Hirani, P L Rowland, R Berkeley, E P Krenzelok.
Abstract
Pseudoephedrine and dextromethorphan are therapeutic constituents of numerous commonly used, over-the-counter cough and cold preparations. Although this drug combination is generally considered quite safe if utilized in recommended doses, overmedication or overdose can result in serious neurologic and cardiovascular abnormalities that occasionally can be life-threatening. We present a case of a 2-year-old child who developed hyperirritability, psychosis, and ataxia after being overmedicated with a pseudoephedrine/dextromethorphan combination cough preparation, and discuss probable mechanisms of toxicity and risk factors for adverse events.Entities:
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Year: 1999 PMID： 10195488 DOI： 10.1016/s0736-4679(98)00193-0
Source DB: PubMed Journal: J Emerg Med ISSN： 0736-4679 Impact factor: 1.484