OBJECTIVES: It has been shown that > 90% of mothers of HTLV-I-infected children were themselves carriers of HTLV-I. This study was designed to determine the HTLV-I serostatus of mothers of patients with adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and to assess the association of age of exposure and disease outcome. STUDY DESIGN/ METHODS: In a cross-sectional study of the HTLV-I serostatus of mothers of HTLV-I-seropositive patients with ATL and HAM/TSP, 36 living mothers of patients with ATL and 15 mothers of patients with TSP/HAM were traced and enrolled. RESULTS: Five of the 15 (33%) mothers of patients with HAM/TSP and 35 of the 36 (97.2%) mothers of patients with ATL were HTLV-I-seropositive. All patients were breast-fed and none received blood transfusions. CONCLUSION: This study confirms that infection with HTLV-I in early childhood can lead to ATL in later life, and that HAM/TSP can also result from early infection but more commonly results from infection acquired in adulthood. There are several reports of posttransfusion HAM/TSP, but ATL has not been reported following blood transfusion except in patients who were immunocompromised. Because the newborn infant is considered to be immunoincompetent, it seems that this is a necessary factor for the development of ATL after infection.
OBJECTIVES: It has been shown that > 90% of mothers of HTLV-I-infectedchildren were themselves carriers of HTLV-I. This study was designed to determine the HTLV-I serostatus of mothers of patients with adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and to assess the association of age of exposure and disease outcome. STUDY DESIGN/ METHODS: In a cross-sectional study of the HTLV-I serostatus of mothers of HTLV-I-seropositivepatients with ATL and HAM/TSP, 36 living mothers of patients with ATL and 15 mothers of patients with TSP/HAM were traced and enrolled. RESULTS: Five of the 15 (33%) mothers of patients with HAM/TSP and 35 of the 36 (97.2%) mothers of patients with ATL were HTLV-I-seropositive. All patients were breast-fed and none received blood transfusions. CONCLUSION: This study confirms that infection with HTLV-I in early childhood can lead to ATL in later life, and that HAM/TSP can also result from early infection but more commonly results from infection acquired in adulthood. There are several reports of posttransfusion HAM/TSP, but ATL has not been reported following blood transfusion except in patients who were immunocompromised. Because the newborn infant is considered to be immunoincompetent, it seems that this is a necessary factor for the development of ATL after infection.
Authors: Prabal Banerjee; Adam Tripp; Michael D Lairmore; Lindsey Crawford; Michelle Sieburg; Juan Carlos Ramos; William Harrington; Mark A Beilke; Gerold Feuer Journal: Blood Date: 2010-02-01 Impact factor: 22.113
Authors: Alison Y Swaims; Francesca Khani; Yingyu Zhang; Arthur I Roberts; Satish Devadas; Yufang Shi; Arnold B Rabson Journal: Blood Date: 2010-07-15 Impact factor: 22.113
Authors: Augustine Ejike Okoye; Obike Godswill Ibegbulam; Robinson Chukwudi Onoh; Paul Olisaemeka Ezeonu; Ngozi I Ugwu; Lucky Osaheni Lawani; Chukwudi Simon Anigbo; Charles E Nonyelu Journal: Int J Womens Health Date: 2014-09-18
Authors: David Sibon; Olivier Cassar; Isabelle Duga; Chantal Brouzes; David Ghez; Christophe Pasquier; Claire Sibon; Alexandra Desrames; Franck Mortreux; Eric Wattel; Ali Bazarbachi; Antoine Gessain; Olivier Hermine Journal: Open Forum Infect Dis Date: 2015-03-06 Impact factor: 3.835