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Literature DB >> 10195179

Miniature synaptic events maintain dendritic spines via AMPA receptor activation.

R A McKinney¹, M Capogna, R Dürr, B H Gähwiler, S M Thompson.

Abstract

We investigated the influence of synaptically released glutamate on postsynaptic structure by comparing the effects of deafferentation, receptor antagonists and blockers of glutamate release in hippocampal slice cultures. CA1 pyramidal cell spine density and length decreased after transection of Schaffer collaterals and after application of AMPA receptor antagonists or botulinum toxin to unlesioned cultures. Loss of spines induced by lesion or by botulinum toxin was prevented by simultaneous AMPA application. Tetrodotoxin did not affect spine density. Synaptically released glutamate thus exerts a trophic effect on spines by acting at AMPA receptors. We conclude that AMPA receptor activation by spontaneous vesicular glutamate release is sufficient to maintain dendritic spines.

Entities: Chemical Disease Gene

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Year: 1999 PMID： 10195179 DOI： 10.1038/4548

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

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Cited

185 in total

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2. Correlation of miniature synaptic activity and evoked release probability in cultures of cortical neurons.

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3. Dynamic regulation of cpg15 during activity-dependent synaptic development in the mammalian visual system.

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5. Activity-dependent regulation of synaptic clustering in a hippocampal culture system.

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Journal: Proc Natl Acad Sci U S A Date: 1999-10-26 Impact factor: 11.205

6. Loss of presynaptic and postsynaptic structures is accompanied by compensatory increase in action potential-dependent synaptic input to layer V neocortical pyramidal neurons in aged rats.

Authors: T P Wong; G Marchese; M A Casu; A Ribeiro-da-Silva; A C Cuello; Y De Koninck
Journal: J Neurosci Date: 2000-11-15 Impact factor: 6.167

Miniature synaptic events maintain dendritic spines via AMPA receptor activation.

1. Functional plasticity triggers formation and pruning of dendritic spines in cultured hippocampal networks.

2. Correlation of miniature synaptic activity and evoked release probability in cultures of cortical neurons.

3. Dynamic regulation of cpg15 during activity-dependent synaptic development in the mammalian visual system.

4. Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses.

5. Activity-dependent regulation of synaptic clustering in a hippocampal culture system.

6. Loss of presynaptic and postsynaptic structures is accompanied by compensatory increase in action potential-dependent synaptic input to layer V neocortical pyramidal neurons in aged rats.

7. Stages of synapse development defined by dependence on F-actin.

8. Remodeling of synaptic membranes after induction of long-term potentiation.

9. Sex differences and opposite effects of stress on dendritic spine density in the male versus female hippocampus.

10. Remodeling of hippocampal synaptic networks by a brief anoxia-hypoglycemia.