| Literature DB >> 10193667 |
G Oroszi1, Z Szilvassy, J Nemeth, P Ferdinandy, J Szolcsanyi, A Tosaki.
Abstract
Capsaicin-induced increases in heart rate and coronary flow were blocked by N(G)-nitro-L-Arg-methyl ester (30 mM) in Langendorff-perfused guinea-pig hearts. Neither heart rate nor coronary flow changed by capsaicin in hearts from animals made tolerant to the hypotensive effect of 30 microg/kg nitroglycerin by the administration of 50 mg/kg nitroglycerin subcutaneously 4 times a day over 3 days. We conclude that the effector function of sensory nerves may deteriorate in nitrate tolerance.Entities:
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Year: 1999 PMID： 10193667 DOI： 10.1016/s0014-2999(99)00056-4
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432