Literature DB >> 10193442

A genetic developmental model of iron deficiency: biological aspects.

A C Morse1, J L Beard, B C Jones.   

Abstract

Numerous studies have demonstrated the negative impact of iron deficiency on growth and development. The present study expands on the published literature by exploring the role of genetics and developmental timing on the impact of iron deficiency on development in two strains of mice. Growth rates, organ weights, and hematological responses to an iron-deficient diet differed by strain and sex. The results from this study provided novel insight into iron metabolism and the impact of iron deficiency in C57 and DBA strains of mice. Future studies should continue to examine the contributions of both genetics and sex to the development of iron deficiency.

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Year:  1999        PMID: 10193442     DOI: 10.1046/j.1525-1373.1999.d01-22.x

Source DB:  PubMed          Journal:  Proc Soc Exp Biol Med        ISSN: 0037-9727


  12 in total

Review 1.  Long-lasting neural and behavioral effects of iron deficiency in infancy.

Authors:  Betsy Lozoff; John Beard; James Connor; Felt Barbara; Michael Georgieff; Timothy Schallert
Journal:  Nutr Rev       Date:  2006-05       Impact factor: 7.110

2.  Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis.

Authors:  R E Fleming; C C Holden; S Tomatsu; A Waheed; E M Brunt; R S Britton; B R Bacon; D C Roopenian; W S Sly
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-27       Impact factor: 11.205

3.  Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice.

Authors:  F Dupic; S Fruchon; M Bensaid; O Loreal; P Brissot; N Borot; M P Roth; H Coppin
Journal:  Gut       Date:  2002-11       Impact factor: 23.059

4.  Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice.

Authors:  Stela McLachlan; Kathryn E Page; Seung-Min Lee; Alex Loguinov; Erika Valore; Simon T Hui; Grace Jung; Jie Zhou; Aldons J Lusis; Brie Fuqua; Tomas Ganz; Elizabeta Nemeth; Chris D Vulpe
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2017-08-10       Impact factor: 4.052

5.  Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses.

Authors:  Wanjiku N Gichohi-Wainaina; G Wayne Towers; Dorine W Swinkels; Michael B Zimmermann; Edith J Feskens; Alida Melse-Boonstra
Journal:  Genes Nutr       Date:  2014-11-22       Impact factor: 5.523

6.  In silico QTL mapping of basal liver iron levels in inbred mouse strains.

Authors:  Stela McLachlan; Seung-Min Lee; Teresa M Steele; Paula L Hawthorne; Matthew A Zapala; Eleazar Eskin; Nicholas J Schork; Gregory J Anderson; Chris D Vulpe
Journal:  Physiol Genomics       Date:  2010-11-09       Impact factor: 3.107

7.  Striking while the iron is hot: Understanding the biological and neurodevelopmental effects of iron deficiency to optimize intervention in early childhood.

Authors:  Jenalee R Doom; Michael K Georgieff
Journal:  Curr Pediatr Rep       Date:  2014-12-01

8.  Altered iron metabolism in lymphocytes from subjects with restless legs syndrome.

Authors:  Christopher J Earley; Padmavathi Ponnuru; Xinsheng Wang; Stephanie M Patton; James R Conner; John L Beard; Dennis D Taub; Richard P Allen
Journal:  Sleep       Date:  2008-06       Impact factor: 5.849

9.  Genome-wide association study identifies genetic loci associated with iron deficiency.

Authors:  Christine E McLaren; Chad P Garner; Clare C Constantine; Stela McLachlan; Chris D Vulpe; Beverly M Snively; Victor R Gordeuk; Debbie A Nickerson; James D Cook; Catherine Leiendecker-Foster; Kenneth B Beckman; John H Eckfeldt; Lisa F Barcellos; Joseph A Murray; Paul C Adams; Ronald T Acton; Anthony A Killeen; Gordon D McLaren
Journal:  PLoS One       Date:  2011-03-31       Impact factor: 3.240

10.  Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations.

Authors:  Christine E McLaren; Stela McLachlan; Chad P Garner; Chris D Vulpe; Victor R Gordeuk; John H Eckfeldt; Paul C Adams; Ronald T Acton; Joseph A Murray; Catherine Leiendecker-Foster; Beverly M Snively; Lisa F Barcellos; James D Cook; Gordon D McLaren
Journal:  PLoS One       Date:  2012-06-22       Impact factor: 3.240

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