Kinetic concepts in the systemic drug therapy of breast cancer.

Optimal management of cancer today requires a thorough and up-to-date understanding of cancer cell kinetics and biochemistry. This report reviews the history and current standards in these fields and how they affect the contemporary approach to breast cancer management. Also outlined are recommended avenues for future research in cytotoxic chemotherapy programs using the principles of cancer cell kinetics as well as the role of newer approaches, including biologic agents such as trastuzumab (Herceptin) and antiangiogenesis agents, in the future therapy of this disease.