Literature DB >> 10189947

Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease.

G Hussein1, H Miyashiro, N Nakamura, M Hattori, T Kawahata, T Otake, N Kakiuchi, K Shimotohno.   

Abstract

Forty-eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication. Nineteen extracts showed inhibitory effects on HIV-induced cytopathic effects (CPE) on MT-4 cells. The extracts were further screened against HIV-1 protease (PR) using an HPLC assay method. Of the tested extracts, the methanol extracts of Acacia nilotica (bark and pods), Euphorbia granulata (leaves), Maytenus senegalensis (stem-bark) and aqueous extracts of A. nilotica (pods) and M. senegalensis (stem-bark) showed considerable inhibitory effects against HIV-1 PR. Inhibitory principles were isolated from M. senegalensis and their activities were also discussed.

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Year:  1999        PMID： 10189947     DOI： 10.1002/(SICI)1099-1573(199902)13:1<31::AID-PTR381>3.0.CO;2-C

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  13 in total

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6.  Studies on Antimicrobial and Immunomodulatory Effects of Hot Aqueous Extract of Acacia nilotica L. Leaves against Common Veterinary Pathogens.

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Journal:  Vet Med Int       Date:  2014-04-07

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