Literature DB >> 10189946

Antihepatotoxic activity of Swertia chirata on carbon tetrachloride induced hepatotoxicity in rats.

M Karan1, K Vasisht, S S Handa.   

Abstract

The methanol extract of Swertia chirata was evaluated for antihepatotoxic activity against carbon tetrachloride induced liver toxicity in experimental rats. The extract was found to be active and on fractionation into butanol soluble and chloroform soluble fractions, the activity was traced and found more profound in the chloroform soluble fraction. The butanol soluble bitter rich fraction showed marginal activity. The results based on biochemical estimations have been expressed statistically and are additionally supported by histopathological examination of the liver of experimental rats and pentobarbitone induced sleep time studies in mice.

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Year:  1999        PMID： 10189946     DOI： 10.1002/(SICI)1099-1573(199902)13:1<24::AID-PTR378>3.0.CO;2-L

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  6 in total

1.  Amelioration of oxidative and inflammatory changes by Swertia chirayita leaves in experimental arthritis.

Authors:  Harsha Lad; Deepak Bhatnagar
Journal:  Inflammopharmacology       Date:  2016-10-14       Impact factor: 4.473

2.  Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats.

Authors:  Hai Zhong Huo; Bing Wang; Yong Kang Liang; Yong Yang Bao; Yan Gu
Journal:  Int J Mol Sci       Date:  2011-10-06       Impact factor: 5.923

3.  The bitter barricading of prostaglandin biosynthesis pathway: understanding the molecular mechanism of selective cyclooxygenase-2 inhibition by amarogentin, a secoiridoid glycoside from Swertia chirayita.

Authors:  Shantanu Shukla; Khushboo Bafna; Durai Sundar; Sunil S Thorat
Journal:  PLoS One       Date:  2014-03-06       Impact factor: 3.240

4.  Hepatoprotective Activity of Cucumis trigonus Roxb. Fruitagainst CCl4 Inducesd Hepatic Damage in Rats.

Authors:  Kalpana Patil; Shaikh Mohammedimtiaz; Anoop Singh; Varsha Bagewadi; Shaikh Gazi
Journal:  Iran J Pharm Res       Date:  2011       Impact factor: 1.696

5.  Protective Effects of Amarogentin against Carbon Tetrachloride-Induced Liver Fibrosis in Mice.

Authors:  Ya Zhang; Hang Zhao; Hua Li; Wei Cao; Fang Wang; Tian Zhang; Si-Wang Wang
Journal:  Molecules       Date:  2017-05-06       Impact factor: 4.411

Review 6.  Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms.

Authors:  Balu Alagar Venmathi Maran; Mohammad Iqbal; Prakash Gangadaran; Byeong-Cheol Ahn; Pasupuleti Visweswara Rao; Muhammad Dawood Shah
Journal:  Molecules       Date:  2022-02-24       Impact factor: 4.411
  6 in total

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