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Literature DB >> 10189231

Antibacterial effect of some 2,6-disubstituted 4-anilinoquinazolines.

Abstract

Two synthetic 2,6-disubstituted 4-anilinoquinazolines exerted a significant effect on the G+ bacteria Bacillus subtilis and staphylococcus aureus. None of 12 tested derivatives influenced Escherichia coli, Proteus mirabilis and Pseudomonas aeruginosa. Derivatives having the aromatic ring non-substituted or substituted by bromine, the pyrimidine ring by phenyl, morpholine or piperidine and the aniline skeleton non-substituted or substituted by methyl or amino group exerted a considerable antibacterial activity.

Entities: Chemical Species

Mesh：

Substances：

Year: 1998 PMID： 10189231 DOI： 10.1007/bf02816389

Source DB: PubMed Journal: Folia Microbiol (Praha) ISSN： 0015-5632 Impact factor: 2.099

12 in total

1. Synthesis of 3-aryl-2-substituted-4(3H)-quinazolines as potential antimicrobial agents.

Authors: A M Farghaly; A Mohsen; M E Omar; M A Khalil; M A Gaber
Journal: Farmaco Date: 1990-04

2. Non-steroidal antiinflammatory agents. Synthesis of novel 2-pyrazolyl-4(3H)-quinazolinones.

Authors: A M Farghaly; I Chaaban; M A Khalil; A A Bekhit
Journal: Arch Pharm (Weinheim) Date: 1990-10 Impact factor: 3.751

Review 3. Folate-based thymidylate synthase inhibitors in cancer chemotherapy.

Authors: Y Takemura; A L Jackman
Journal: Anticancer Drugs Date: 1997-01 Impact factor: 2.248

4. Antibacterial effect of substituted 4-quinazolyl-hydrazines and their arylhydrazones determined by a modified microdilution method.

Authors: S Jantová; D Hudecová; S Stankovský; K Spirková; L Ruzeková
Journal: Folia Microbiol (Praha) Date: 1995 Impact factor: 2.099

5. Structure-activity relationships for 4-anilinoquinazolines as potent inhibitors at the ATP binding site of the epidermal growth factor receptor in vitro.

Authors: W A Denny; G W Rewcastle; A J Bridges; D W Fry; A J Kraker
Journal: Clin Exp Pharmacol Physiol Date: 1996-05 Impact factor: 2.557

6. Relationships between the structure, cytotoxicity and hydrophobicity of quinazoline derivatives by quantitative structure-activity relationship.

Authors: S Jantová; S Baláz; S Stankovský; K Spirková; V Lukácová
Journal: Folia Biol (Praha) Date: 1997 Impact factor: 0.906

7. Antimicrobial effects of the macrocyclic Cu(II)-tetraanhydroaminobenzaldehyde complex.

Authors: S Jantová; J Labuda; V Vollek; M Zastková
Journal: Folia Microbiol (Praha) Date: 1997 Impact factor: 2.099

8. Synthesis and antibacterial activity of certain quinoline and quinazoline derivatives containing sulfide and sulfone moieties.

Authors: M F el-Zohry; A A Ahmed; F A Omar; M A Abd-Alla
Journal: J Chem Technol Biotechnol Date: 1992 Impact factor: 3.174

Antibacterial effect of some 2,6-disubstituted 4-anilinoquinazolines.

1. Synthesis of 3-aryl-2-substituted-4(3H)-quinazolines as potential antimicrobial agents.

2. Non-steroidal antiinflammatory agents. Synthesis of novel 2-pyrazolyl-4(3H)-quinazolinones.

Review 3. Folate-based thymidylate synthase inhibitors in cancer chemotherapy.

4. Antibacterial effect of substituted 4-quinazolyl-hydrazines and their arylhydrazones determined by a modified microdilution method.

5. Structure-activity relationships for 4-anilinoquinazolines as potent inhibitors at the ATP binding site of the epidermal growth factor receptor in vitro.

6. Relationships between the structure, cytotoxicity and hydrophobicity of quinazoline derivatives by quantitative structure-activity relationship.

7. Antimicrobial effects of the macrocyclic Cu(II)-tetraanhydroaminobenzaldehyde complex.

8. Synthesis and antibacterial activity of certain quinoline and quinazoline derivatives containing sulfide and sulfone moieties.

9. Synthesis and anticonvulsant activity of new acylthiosemicarbazides and thiazolidones.

10. 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone sodium salt (MDL 427): a new antiallergic agent.

1. Antibacterial effect of some substituted tricyclic quinazolines and their synthetic precursors.

2. Selective medium for primary isolation of members of the tribe Proteeae.

3. Docking study, synthesis and antimicrobial evaluation of some novel 4-anilinoquinazoline derivatives.