OBJECTIVES: To evaluate whether heavy cigarette smoking as a teenager or long-term smoking increases breast cancer risk or, alternatively, whether smoking acts as an anti-estrogen and reduces risk. METHODS: Data from a multi-center, population-based, case-control study among women under age 55 were analyzed. RESULTS: Among women under age 45, there was a modest inverse relation with current (OR = 0.82, 95% CI = 0.67, 1.01) but not past (OR = 0.99, 95% CI = 0.81, 1.21) smoking. Odds ratios were decreased for current smokers who began at an early age (0.59 for < or = 15, 95% CI = 0.41, 0.85) or continued for long periods of time (0.70 for >21 years, 95% CI = 0.52, 0.94). In subgroup analyses, reduced odds ratios were observed among current smokers who were ever users of oral contraceptives (0.79, 95% CI = 0.63, 0.98), were in the lowest quartile of adult body size (0.53, 95% CI = 0.34, 0.81), or never or infrequently drank alcohol (0.68, 95% CI = 0.47, 0.98). Among women ages 45-54, there was little evidence for an association with smoking. CONCLUSIONS: These results suggest that breast cancer risk among women under age 45 may be reduced among current smokers who began smoking at an early age, or long-term smokers, but require confirmation from other studies.
OBJECTIVES: To evaluate whether heavy cigarette smoking as a teenager or long-term smoking increases breast cancer risk or, alternatively, whether smoking acts as an anti-estrogen and reduces risk. METHODS: Data from a multi-center, population-based, case-control study among women under age 55 were analyzed. RESULTS: Among women under age 45, there was a modest inverse relation with current (OR = 0.82, 95% CI = 0.67, 1.01) but not past (OR = 0.99, 95% CI = 0.81, 1.21) smoking. Odds ratios were decreased for current smokers who began at an early age (0.59 for < or = 15, 95% CI = 0.41, 0.85) or continued for long periods of time (0.70 for >21 years, 95% CI = 0.52, 0.94). In subgroup analyses, reduced odds ratios were observed among current smokers who were ever users of oral contraceptives (0.79, 95% CI = 0.63, 0.98), were in the lowest quartile of adult body size (0.53, 95% CI = 0.34, 0.81), or never or infrequently drank alcohol (0.68, 95% CI = 0.47, 0.98). Among women ages 45-54, there was little evidence for an association with smoking. CONCLUSIONS: These results suggest that breast cancer risk among women under age 45 may be reduced among current smokers who began smoking at an early age, or long-term smokers, but require confirmation from other studies.
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Authors: Xiaochen Dai; Gabriela F Gil; Marissa B Reitsma; Noah S Ahmad; Jason A Anderson; Catherine Bisignano; Sinclair Carr; Rachel Feldman; Simon I Hay; Jiawei He; Vincent Iannucci; Hilary R Lawlor; Matthew J Malloy; Laurie B Marczak; Susan A McLaughlin; Larissa Morikawa; Erin C Mullany; Sneha I Nicholson; Erin M O'Connell; Chukwuma Okereke; Reed J D Sorensen; Joanna Whisnant; Aleksandr Y Aravkin; Peng Zheng; Christopher J L Murray; Emmanuela Gakidou Journal: Nat Med Date: 2022-10-10 Impact factor: 87.241