Literature DB >> 10153429

Implementing a policy for pneumococcal prophylaxis in a haematology unit after splenectomy.

S G Long1, A G Smith, B A Perry, M J Leyland, D W Milligan.   

Abstract

People who have had a splenectomy for any reason are 40 times more likely to have an overwhelming infection, especially pneumococcal infection, and 17 times more likely to suffer fatal sepsis. The incidence of such life threatening infections is reduced by prophylactic immunisation with polyvalent pneumococcal vaccine and long term antibiotic prophylaxis or instituting prompt antibiotic treatment in the event of fever. This haematology unit agreed a policy of immunisation and antibiotic prophylaxis in June 1988 for all patients undergoing elective splenectomy. The success of this policy was audited in July 1993 by a retrospective analysis of patients' case notes. Seventy four patients were identified as having had a splenectomy, 54 (73%) before June 1988, of whom only 13 (24%) had received both pneumococcal immunisation and antibiotic prophylaxis before implementation of the agreed policy. At the time of audit, 46/74 (62%) patients were recorded as having received immunisation and 64/74 (86%) as receiving antibiotic prophylaxis or a supply of antibiotics to take in the event of a fever. All but one of the 20 patients who had a splenectomy after June 1988, since implementation of the agreed policy, received immunisation and antibiotic prophylaxis. The authors conclude that establishment of a formal agreed policy for pneumococcal prophylaxis for patients undergoing splenectomy has improved the quality of care.

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Year:  1995        PMID: 10153429      PMCID: PMC1055316          DOI: 10.1136/qshc.4.3.194

Source DB:  PubMed          Journal:  Qual Health Care        ISSN: 0963-8172


  7 in total

1.  Comment: pneumococcal revaccination.

Authors:  J D Grabenstein
Journal:  DICP       Date:  1989-03

Review 2.  Splenectomy and sepsis: a warning.

Authors:  J D Dickerman
Journal:  Pediatrics       Date:  1979-06       Impact factor: 7.124

3.  Pneumococcal vaccine efficacy in selected populations in the United States.

Authors:  G Bolan; C V Broome; R R Facklam; B D Plikaytis; D W Fraser; W F Schlech
Journal:  Ann Intern Med       Date:  1986-01       Impact factor: 25.391

4.  Long term management of patients after splenectomy.

Authors:  M McMullin; G Johnston
Journal:  BMJ       Date:  1993-11-27

Review 5.  Complications of splenectomy. Etiology, prevention, and management.

Authors:  E C Ellison; P J Fabri
Journal:  Surg Clin North Am       Date:  1983-12       Impact factor: 2.741

6.  Continued need for pneumococcal prophylaxis after splenectomy.

Authors:  I A Murdoch; R Dos Anjos
Journal:  Arch Dis Child       Date:  1990-11       Impact factor: 3.791

Review 7.  Rarity of failure of penicillin prophylaxis to prevent postsplenectomy sepsis.

Authors:  M H Zarrabi; F Rosner
Journal:  Arch Intern Med       Date:  1986-06
  7 in total
  1 in total

1.  Overwhelming infection in asplenic patients: current best practice preventive measures are not being followed.

Authors:  D J Waghorn
Journal:  J Clin Pathol       Date:  2001-03       Impact factor: 3.411

  1 in total

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