Literature DB >> 101423

Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease.

D W Harris, P R Smith, C H Swan.   

Abstract

A method is described for determining prostaglandin synthetase activity in milligram amounts of tissue. The procedure is based on the conversion of 14C-arachidonic acid to prostaglandin E2 and F2alpha-like substances. High levels of prostaglandin synthetase activity occurred in the inflamed mucosa of patients with ulcerative colitis and fell during successful drug therapy, but it is not yet known whether the cause of the inflammation first involves increased PG synthetase activity, or whether inflammation caused increase of PG synthetase.

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Year:  1978        PMID： 101423      PMCID： PMC1412356          DOI： 10.1136/gut.19.10.875

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  12 in total

1.  PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS.

Authors:  K GREEN; B SAMUELSSON
Journal:  J Lipid Res       Date:  1964-01       Impact factor: 5.922

2.  Differential inhibition of prostaglandin synthetase and soybean lipoxygenase.

Authors:  D T Downing
Journal:  Prostaglandins       Date:  1972-06

3.  A rapid spectrophotometric assay for prostaglandin synthetase: application to the study of non-steroidal antiinflammatory agents.

Authors:  C Takeguchi; C J Sih
Journal:  Prostaglandins       Date:  1972-09

4.  High-dose intravenous administration of prostaglandin E 2 and F 2 for the termination of midtrimester pregnancies.

Authors:  K Hillier; M P Embrey
Journal:  J Obstet Gynaecol Br Commonw       Date:  1972-01

5.  Prostaglandin production by mouse fibrosarcoma cells in culture: inhibition by indomethacin and aspirin.

Authors:  L Levine; P M Hinkle; E F Voelkel; A H Tashjian
Journal:  Biochem Biophys Res Commun       Date:  1972-05-26       Impact factor: 3.575

6.  Metabolism of prostaglandin E2 in the rat.

Authors:  K Gréen
Journal:  Biochemistry       Date:  1971-03-16       Impact factor: 3.162

7.  Letter: Prostaglandins, ulcerative colitis, and sulphasalazine.

Authors:  S R Gould
Journal:  Lancet       Date:  1975-11-15       Impact factor: 79.321

8.  Inactivation of prostaglandins by the lungs.

Authors:  P J Piper; J R Vane; J H Wyllie
Journal:  Nature       Date:  1970-02-14       Impact factor: 49.962

9.  Extraction of prostaglandins from human blood.

Authors:  W G Unger; I F Stamford; A Bennett
Journal:  Nature       Date:  1971-10-01       Impact factor: 49.962

10.  Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma.

Authors:  B M Jaffe; H R Behrman; C W Parker
Journal:  J Clin Invest       Date:  1973-02       Impact factor: 14.808
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  25 in total

Review 1.  Sulfasalazine. Multiplicity of action.

Authors:  T S Gaginella; R E Walsh
Journal:  Dig Dis Sci       Date:  1992-06       Impact factor: 3.199

Review 2.  Inflammatory intermediaries in inflammatory bowel disease.

Authors:  K Lauritsen; L S Laursen; K Bukhave; J Rask-Madsen
Journal:  Int J Colorectal Dis       Date:  1989       Impact factor: 2.571

3.  n-3 fatty acids only delay early relapse of ulcerative colitis in remission.

Authors:  K Loeschke; B Ueberschaer; A Pietsch; E Gruber; K Ewe; B Wiebecke; W Heldwein; R Lorenz
Journal:  Dig Dis Sci       Date:  1996-10       Impact factor: 3.199

4.  Do eicosanoids cause colonic dysfunction in experimental E coli O157:H7 (EHEC) infection?

Authors:  C J Bell; E J Elliott; J L Wallace; D M Redmond; J Payne; Z Li; E V O'Loughlin
Journal:  Gut       Date:  2000-06       Impact factor: 23.059

5.  Ulcerative colitis: effect of sulphasalazine, its metabolites and indomethacin on the ability of human colonic mucosa to metabolize prostaglandins in vitro.

Authors:  K Hillier; P J Mason; S Pacheco; C L Smith
Journal:  Br J Pharmacol       Date:  1982-05       Impact factor: 8.739

6.  Increased suppressor cell activity in inflammatory bowel disease.

Authors:  G Holdstock; B F Chastenay; E L Krawitt
Journal:  Gut       Date:  1981-12       Impact factor: 23.059

7.  Relapse of ulcerative proctocolitis during treatment with non-steroidal anti-inflammatory drugs.

Authors:  D S Rampton; G E Sladen
Journal:  Postgrad Med J       Date:  1981-05       Impact factor: 2.401

8.  Increased phospholipase A2 activity in peritoneal leukocytes in rat experimental colitis.

Authors:  S N Murthy; R J Biondi
Journal:  Inflammation       Date:  1992-06       Impact factor: 4.092

9.  Effects of sulphasalazine and disodium azodisalicylate on colonic PGE2 concentrations determined by equilibrium in vivo dialysis of faeces in patients with ulcerative colitis and healthy controls.

Authors:  K Lauritsen; J Hansen; P Bytzer; K Bukhave; J Rask-Madsen
Journal:  Gut       Date:  1984-11       Impact factor: 23.059

10.  Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.

Authors:  N K Boughton-Smith; C J Hawkey; B J Whittle
Journal:  Gut       Date:  1983-12       Impact factor: 23.059
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