Literature DB >> 10141

N-Hydroxylation of phenacetin by hamster liver microsomes.

J A Hinson, J R Mitchell.   

Abstract

Hamster liver microsomes have been shown to catalyze the N-hydroxylation of phenacetin. The reaction, which requires oxygen and NADPH, is inhibited by a carbon monoxide/oxygen atmosphere, indicating that it is catalyzed by a cytochrome P-450-dependent mixed-function oxidase. The N-hydroxyphenacetin can be further metabolized by the microsomes, and the reaction is inhibited by phenacetin.

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Year:  1976        PMID： 10141

Source DB:  PubMed          Journal:  Drug Metab Dispos        ISSN： 0090-9556            Impact factor:   3.922


  5 in total

1.  Metabolism of phenacetin and N-hydroxyphenacetin in isolated rat hepatocytes.

Authors:  S McLean
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-11       Impact factor: 3.000

2.  N-Hydroxy-N-arylacetamides. I. Toxicity of certain polycyclic and monocyclic N-hydroxy-N-arylacetamides in rats.

Authors:  T Fischbach; H Hertle; M Kiese; W Lenk; H Sterzl; P Meister
Journal:  Arch Toxicol       Date:  1984-12       Impact factor: 5.153

3.  Reduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1.

Authors:  Kai Wang; F Peter Guengerich
Journal:  Chem Res Toxicol       Date:  2013-05-29       Impact factor: 3.739

4.  Formation of N-hydroxy-N-arylacetamides from nitroso aromatic compounds by the mammalian pyruvate dehydrogenase complex.

Authors:  T Yoshioka; T Uematsu
Journal:  Biochem J       Date:  1993-03-15       Impact factor: 3.857

Review 5.  Reactive metabolites of phenacetin and acetaminophen: a review.

Authors:  J A Hinson
Journal:  Environ Health Perspect       Date:  1983-03       Impact factor: 9.031
  5 in total

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