Literature DB >> 1012999

Penetration of digoxin into cerebrospinal fluid.

G D Schott, D W Holt, A M Hayler.   

Abstract

The concentration of digoxin in the cerebrospinal fluid (CSF) of ten patients receiving conventional oral doses of this cardiac glycoside has been measured by a radioimmunoassay technique. Digoxin was undetected in eight patients and barely detectable in two, suggesting the presence of a significant blood-CSF barrier for digoxin. The implication of these findings is discussed.

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Year:  1976        PMID: 1012999      PMCID: PMC2496338          DOI: 10.1136/pgmj.52.613.700

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN: 0032-5473            Impact factor:   2.401


  8 in total

1.  Digitalis: A neuroexcitatory drug.

Authors:  R A Gillis
Journal:  Circulation       Date:  1975-11       Impact factor: 29.690

2.  Postmortem assay of digoxin by radioimmunoassay.

Authors:  D W Holt; J G Benstead
Journal:  J Clin Pathol       Date:  1975-06       Impact factor: 3.411

3.  Letter: Digoxin in benign intracranial hypertension.

Authors:  G D Schott; D Holt
Journal:  Lancet       Date:  1974-03-02       Impact factor: 79.321

4.  Letter: Concentration of digoxin in choroid plexus.

Authors:  A Bertler; K E Andersson; G Wettrell
Journal:  Lancet       Date:  1973-12-22       Impact factor: 79.321

5.  Effect of cardiac glycosides on human cerebrospinal-fluid production.

Authors:  C R Neblett; T A Waltz; D P McNeel; G M Harrison
Journal:  Lancet       Date:  1972-11-11       Impact factor: 79.321

6.  The distribution and concentration of tritiated digoxin in human tissues.

Authors:  J E Doherty; W H Perkins; W J Flanigan
Journal:  Ann Intern Med       Date:  1967-01       Impact factor: 25.391

7.  Trial of digoxin in mania.

Authors:  G J Naylor; E P Worrall; Y Watson; P Dick; M Stewart; M Peet
Journal:  Lancet       Date:  1975-10-04       Impact factor: 79.321

8.  The central nervous system as a site of action for the coronary vasoconstrictor effect of digoxin.

Authors:  H Garan; T W Smith; W J Powell
Journal:  J Clin Invest       Date:  1974-12       Impact factor: 14.808

  8 in total

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