Comparison of 99mTc-labelled hepatobiliary agents-- 99mTc-pyridoxylidene glutamate (99mTc-PG) and 99mTc-Sn-lidocaine iminodiacetic acid (99mTc-Sn-LIDA).

The time-course of excretion of two hepatobiliary radiopharmaceuticals, 99mTc-pyridoxylidene glutamate (99mTc-PG) and 99mTc-Sn-lidocaine iminodiacetic acid (99mTc-Sn-LIDA), from the circulatorysystem to the parenchymal structures, and into the biliary duct and gastrointestinal tract in the same normal human subjects has been studied. The initial blood clearance is faster with 99mTc-Sn-LIDA whereas the initial excretion form the gallbladder to the gut is a little faster with 99mTc-PG. Kidney uptake is seen with both the radiopharmaceuticals, and is a little more with 99mTc-PG.