Literature DB >> 10115

The influence of histamine on epithelial cell proliferation in the jejunum of the rat.

P J Tutton.   

Abstract

1. The influence of histamine and histamine receptor blockade on the mitotic rate in epithelial cell proliferation in epithelial cells lining the crypts of Lieberkühn in rat jejunum was studied. 2. Histamine injection resulted in an increase in the mitotic rate. This increase in mitotic rate was blocked by metiamide but not by mepyramine. 3. Prevention of histamine synthesis by alpha-methylhistidine administration did not alter the mitotic rate. 4. The mechanism by which histamine may influence crypt cell proliferation and possible role of cyclic GMP in this mediation are discussed.¿

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Year:  1976        PMID： 10115     DOI： 10.1111/j.1440-1681.1976.tb00613.x

Source DB:  PubMed          Journal:  Clin Exp Pharmacol Physiol        ISSN： 0305-1870            Impact factor:   2.557


  14 in total

1.  Histamine and histidine decarboxylase are correlated with mucosal repair in rat small intestine after ischemia-reperfusion.

Authors:  K Fujimoto; I Imamura; D N Granger; H Wada; T Sakata; P Tso
Journal:  J Clin Invest       Date:  1992-01       Impact factor: 14.808

2.  Diamine oxidase activities in the large bowel mucosa of ulcerative colitis patients.

Authors:  R Mennigen; J Kusche; C Streffer; B Krakamp
Journal:  Agents Actions       Date:  1990-04

3.  N-methyl-N-formylhydrazine: a toxic and mutagenic inhibitor of the intestinal diamine oxidase.

Authors:  T Biegański; R Braun; J Kusche
Journal:  Agents Actions       Date:  1984-04

4.  Elevation of the large bowel histamine concentration by aminoguanidine induced diamine oxidase inhibition.

Authors:  J Kusche; R Mennigen; L Leisten; B Amoei
Journal:  Agents Actions       Date:  1987-04

5.  Evaluation of the cytotoxicity of dihydroxytryptamines and 5-hydroxytryptamine antagonists as cytotoxic agents in dimethylhydrazine-induced adenocarcinomata.

Authors:  P J Tutton; D H Barkla
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

6.  The histamine-diamine oxidase system and mucosal proliferation under the influence of aminoguanidine and seventy percent resection of the rat small intestine.

Authors:  R Mennigen; T Bieganski; A Elbers; J Kusche
Journal:  Agents Actions       Date:  1989-04

7.  Measurement of glycoprotein content and cell kinetics in preulcerous gastric mucosa.

Authors:  F Andre; C Andre; S Fournier
Journal:  Dig Dis Sci       Date:  1979-09       Impact factor: 3.199

8.  Increased tissue concentrations of histamine in the duodenal mucosa of children with coeliac disease.

Authors:  D N Challacombe; P D Dawkins
Journal:  J Clin Pathol       Date:  1982-06       Impact factor: 3.411

9.  Large bowel tumors and diamine oxidase (DAO) activity in patients: a new approach for risk group identification.

Authors:  R Mennigen; J Kusche; B Krakamp; A Elbers; B Amoei; M Kessebohm; H Sommer
Journal:  Agents Actions       Date:  1988-04

10.  The response of histamine degrading enzymes to nematode infection.

Authors:  W A Fogel; J Dastych; C Maśliński
Journal:  Agents Actions       Date:  1988-04
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