Studies on the physiology and biochemistry of female genital tract of albino rats: response of uterus, cervix and vagina to two different dose ratios of estrogen and progesterone.

Effect of two different dose ratios of estrogen (E) and progesterone (P) (1:1000; 1:10,000) on the morphological and biochemical response of the uterus, cervix and the vagina of ovariectomized estrogen pretreated rats was studied. It was observed that the dose ratio of E & P at 1:1000 did not produce any remarkable ponderal and histological changes from that seen under the influence of estrogen alone. Whereas, in the dose ratio of E & P at 1:10,000 progesterone appeared to inhibit the effect of estrogen. The biochemical response of the uterus, cervix and vagina, however, varied from each other in both the dose ratios.