Literature DB >> 10103216

Effect of 3-hydroxyphthaloyl-beta-lactoglobulin on vaginal transmission of simian immunodeficiency virus in rhesus monkeys.

M S Wyand1, K H Manson, C J Miller, A R Neurath.   

Abstract

Heterosexual transmission of human immunodeficiency virus type 1 (HIV-1) is the major cause of the ongoing AIDS epidemic. Application of chemical barrier methods is expected to contribute to the worldwide control of this epidemic. Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride (3-hydroxyphthalovyl-beta-lactoglobulin [3HP-beta-LG]) was shown to inhibit HIV-1, HIV-2, simian immunodeficiency virus (SIV), herpes simplex virus type 1 and 2, and Chlamydia trachomatis infection in vitro. Here, we show that 3HP-beta-LG not formulated into any vehicle protected three of six rhesus monkeys against vaginal infection by SIV. Incorporation of the compound into an appropriate vehicle is expected to increase the degree of protection. 3HP-beta-LG may be effective as a vaginal inhibitor of HIV-1 infection in humans.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10103216      PMCID： PMC89242     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Chemically modified bovine beta-lactoglobulin blocks uptake of HIV-1 by colon- and cervix-derived epithelial cell lines.

Authors:  S Jiang; K Lin; N Strick; Y Y Li; A R Neurath
Journal:  J Acquir Immune Defic Syndr Hum Retrovirol       Date:  1996-12-15

2.  SIV/DeltaB670 transmission across oral, colonic, and vaginal mucosae in the macaque.

Authors:  A M Trichel; E D Roberts; L A Wilson; L N Martin; R M Ruprecht; M Murphey-Corb
Journal:  J Med Primatol       Date:  1997 Feb-Apr       Impact factor: 0.667

3.  Genetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmission.

Authors:  T Zhu; N Wang; A Carr; D S Nam; R Moor-Jankowski; D A Cooper; D D Ho
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

4.  In vivo replication capacity rather than in vitro macrophage tropism predicts efficiency of vaginal transmission of simian immunodeficiency virus or simian/human immunodeficiency virus in rhesus macaques.

Authors:  C J Miller; M Marthas; J Greenier; D Lu; P J Dailey; Y Lu
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

5.  Vaccine protection by a triple deletion mutant of simian immunodeficiency virus.

Authors:  M S Wyand; K H Manson; M Garcia-Moll; D Montefiori; R C Desrosiers
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

6.  3-Hydroxyphthaloyl beta-lactoglobulin. III. Antiviral activity against herpesviruses.

Authors:  A R Neurath; N Strick; Y Y Li
Journal:  Antivir Chem Chemother       Date:  1998-03

7.  Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride blocks the CD4 cell receptor for HIV.

Authors:  A R Neurath; S Jiang; N Strick; K Lin; Y Y Li; A K Debnath
Journal:  Nat Med       Date:  1996-02       Impact factor: 53.440

8.  Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV.

Authors:  T W Baba; A M Trichel; L An; V Liska; L N Martin; M Murphey-Corb; R M Ruprecht
Journal:  Science       Date:  1996-06-07       Impact factor: 47.728

9.  Pathology and localization of simian immunodeficiency virus in the reproductive tract of chronically infected male rhesus macaques.

Authors:  C J Miller; P Vogel; N J Alexander; S Dandekar; A G Hendrickx; P A Marx
Journal:  Lab Invest       Date:  1994-02       Impact factor: 5.662

10.  Mucosal infection of neonatal rhesus monkeys with cell-free SIV.

Authors:  T W Baba; J Koch; E S Mittler; M Greene; M Wyand; D Penninck; R M Ruprecht
Journal:  AIDS Res Hum Retroviruses       Date:  1994-04       Impact factor: 2.205
View more
  5 in total

1.  Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus.

Authors:  Christopher J Miller; Qingsheng Li; Kristina Abel; Eun-Young Kim; Zhong-Min Ma; Stephen Wietgrefe; Lisa La Franco-Scheuch; Lara Compton; Lijie Duan; Marta Dykhuizen Shore; Mary Zupancic; Marc Busch; John Carlis; Steven Wolinsky; Steven Wolinksy; Ashley T Haase
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

2.  The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques.

Authors:  Yichuan Wang; Kristina Abel; Katherine Lantz; Arthur M Krieg; Michael B McChesney; Christopher J Miller
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

3.  Effect of a cellulose acetate phthalate topical cream on vaginal transmission of simian immunodeficiency virus in rhesus monkeys.

Authors:  K H Manson; M S Wyand; C Miller; A R Neurath
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

4.  Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges.

Authors:  Zandrea Ambrose; Lara Compton; Michael Piatak; Ding Lu; W Gregory Alvord; Mariusz S Lubomirski; James E K Hildreth; Jeffrey D Lifson; Christopher J Miller; Vineet N KewalRamani
Journal:  J Virol       Date:  2008-04-23       Impact factor: 5.103

5.  The Underlying Mechanism of 3-Hydroxyphthalic Anhydride-Modified Bovine Beta-Lactoglobulin to Block Human Papillomavirus Entry Into the Host Cell.

Authors:  Chen Hua; Yun Zhu; Congquan Wu; Lulu Si; Qian Wang; Long Sui; Shibo Jiang
Journal:  Front Microbiol       Date:  2019-09-26       Impact factor: 5.640
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.