Literature DB >> 10103214

Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits.

D P Callender1, N Jayaprakash, A Bell, V Petraitis, R Petraitiene, M Candelario, R Schaufele, J M Dunn, S Sei, T J Walsh, F M Balis, R Petratienes.   

Abstract

The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.

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Year:  1999        PMID： 10103214      PMCID： PMC89240     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites.

Authors:  M G Barry; S H Khoo; G J Veal; P G Hoggard; S E Gibbons; E G Wilkins; O Williams; A M Breckenridge; D J Back
Journal:  AIDS       Date:  1996-10       Impact factor: 4.177

2.  Pharmacokinetics of zidovudine administered intravenously and orally in children with human immunodeficiency virus infection.

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Journal:  J Pediatr       Date:  1989-05       Impact factor: 4.406

3.  Chronic silastic central venous catheterization for induction, maintenance and support of persistent granulocytopenia in rabbits.

Authors:  T J Walsh; J Bacher; P A Pizzo
Journal:  Lab Anim Sci       Date:  1988-08

4.  In vivo evaluation of zidovudine (AZT)-loaded ethylcellulose microspheres after oral administration in beagle dogs.

Authors:  K Abu-Izza; L Tambrallo; D R Lu
Journal:  J Pharm Sci       Date:  1997-05       Impact factor: 3.534

5.  Noncompartmental determination of the steady-state volume of distribution for any mode of administration.

Authors:  D Perrier; M Mayersohn
Journal:  J Pharm Sci       Date:  1982-03       Impact factor: 3.534

6.  Preparation of biodegradable microcapsules containing zidovudine (AZT) using solvent evaporation technique.

Authors:  T K Mandal; A Lopez-Anaya; E Onyebueke; M Shekleton
Journal:  J Microencapsul       Date:  1996 May-Jun       Impact factor: 3.142

Review 7.  Clinical pharmacokinetics of zidovudine. An update.

Authors:  E P Acosta; L M Page; C V Fletcher
Journal:  Clin Pharmacokinet       Date:  1996-04       Impact factor: 6.447

8.  Preparation and evaluation of sustained release AZT-loaded microspheres: optimization of the release characteristics using response surface methodology.

Authors:  K A Abu-Izza; L Garcia-Contreras; D R Lu
Journal:  J Pharm Sci       Date:  1996-02       Impact factor: 3.534

9.  The pharmacokinetics of zidovudine administered by continuous infusion in children.

Authors:  F M Balis; P A Pizzo; R F Murphy; J Eddy; P F Jarosinski; J Falloon; S Broder; D G Poplack
Journal:  Ann Intern Med       Date:  1989-02-15       Impact factor: 25.391
  9 in total
  4 in total

1.  Gliadin nanoparticles as carriers for the oral administration of lipophilic drugs. Relationships between bioadhesion and pharmacokinetics.

Authors:  M A Arangoa; M A Campanero; M J Renedo; G Ponchel; J M Irache
Journal:  Pharm Res       Date:  2001-11       Impact factor: 4.200

2.  Improved Safety, Bioavailability and Pharmacokinetics of Zidovudine through Lactoferrin Nanoparticles during Oral Administration in Rats.

Authors:  Prashant Kumar; Yeruva Samrajya Lakshmi; Bhaskar C; Kishore Golla; Anand K Kondapi
Journal:  PLoS One       Date:  2015-10-13       Impact factor: 3.240

3.  Composite alginate hydrogel microparticulate delivery system of zidovudine hydrochloride based on counter ion induced aggregation.

Authors:  Harekrishna Roy; P Venkateswar Rao; Sanjay Kumar Panda; Asim Kumar Biswal; Kirti Ranjan Parida; Jharana Dash
Journal:  Int J Appl Basic Med Res       Date:  2014-09

4.  Alginate nanoparticles as a promising adjuvant and vaccine delivery system.

Authors:  F Sarei; N Mohammadpour Dounighi; H Zolfagharian; P Khaki; S Moradi Bidhendi
Journal:  Indian J Pharm Sci       Date:  2013-07       Impact factor: 0.975
  4 in total

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