OBJECTIVE: The purpose of this study was to evaluate the effects of chemotherapy on oral and dental structures and craniofacial growth in 30 survivors of childhood lymphoma. STUDY DESIGN: Eruption status, root malformations, premature apexification, agenesis, crown anomalies, soft tissue abnormalities, gingival and periodontal status, enamel defects and discolorations, and craniofacial growth status of the subjects were documented and compared with findings in 20 healthy children who served as controls. RESULTS: Statistically significant (P < .05) differences between the study and control groups were found for plaque index, enamel hypoplasias, discolorations, and agenesis. CONCLUSIONS: The results of the study suggest that antineoplastic therapy and/or childhood cancer can result in a higher prevalence of various malformations in teeth. Children treated in the early years of their lives displayed the most severe dental defects, suggesting that immature teeth are at a greater risk of developmental disturbances than fully developed teeth.
OBJECTIVE: The purpose of this study was to evaluate the effects of chemotherapy on oral and dental structures and craniofacial growth in 30 survivors of childhood lymphoma. STUDY DESIGN: Eruption status, root malformations, premature apexification, agenesis, crown anomalies, soft tissue abnormalities, gingival and periodontal status, enamel defects and discolorations, and craniofacial growth status of the subjects were documented and compared with findings in 20 healthy children who served as controls. RESULTS: Statistically significant (P < .05) differences between the study and control groups were found for plaque index, enamel hypoplasias, discolorations, and agenesis. CONCLUSIONS: The results of the study suggest that antineoplastic therapy and/or childhood cancer can result in a higher prevalence of various malformations in teeth. Children treated in the early years of their lives displayed the most severe dental defects, suggesting that immature teeth are at a greater risk of developmental disturbances than fully developed teeth.
Authors: Prasad L Gawade; Melissa M Hudson; Sue C Kaste; Joseph P Neglia; Louis S Constine; Leslie L Robison; Kirsten K Ness Journal: Pediatr Blood Cancer Date: 2013-11-01 Impact factor: 3.167
Authors: Sue C Kaste; Pamela Goodman; Wendy Leisenring; Marilyn Stovall; Robert J Hayashi; Mark Yeazel; Soraya Beiraghi; Melissa M Hudson; Charles A Sklar; Leslie L Robison; K Scott Baker Journal: Cancer Date: 2009-12-15 Impact factor: 6.860
Authors: Catherine H L Hong; Joel J Napeñas; Brian D Hodgson; Monique A Stokman; Vickie Mathers-Stauffer; Linda S Elting; Fred K L Spijkervet; Michael T Brennan Journal: Support Care Cancer Date: 2010-05-07 Impact factor: 3.603
Authors: Adepitan A Owosho; Paul Brady; Suzanne L Wolden; Leonard H Wexler; Cristina R Antonescu; Joseph M Huryn; Cherry L Estilo Journal: Pediatr Hematol Oncol Date: 2016-09-30 Impact factor: 1.969