| Literature DB >> 10100640 |
I Callebaut1, J C Courvalin, J P Mornon.
Abstract
Using sensitive methods of sequence analysis including hydrophobic cluster analysis, we report here a hitherto undescribed family of modules, the BAH (bromo-adjacent homology) family, which includes proteins such as eukaryotic DNA (cytosine-5) methyltransferases, the origin recognition complex 1 (Orc1) proteins, as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialized in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH module might therefore play an important role by linking DNA methylation, replication and transcriptional regulation.Entities:
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Year: 1999 PMID： 10100640 DOI： 10.1016/s0014-5793(99)00132-5
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124