Literature DB >> 10099586

Biosynthesis and ultrasonic degradation of bacterial poly(gamma-glutamic acid).

G Pérez-Camero1, F Congregado, J J Bou, S Muñoz-Guerra.   

Abstract

A study of the production of poly(gamma-glutamic acid) (PGGA) by Bacillus licheniformis NCIMB 11709 grown on medium E in shake flasks at 30 degrees C is reported. The enantiomeric composition of PGGA was found to be highly sensitive to the concentration of Mn++, especially when the ion is present in small amounts (</= 20 microM). Polymers with D-unit contents ranging from 10 to 90% and Mw between 0.4 and 2.0 million g mol-1 were obtained for [Mn++] ranging from 0 to 1230 microM. Ultrasonic degradation was proven to be an effective method to reduce both the molecular weight and the polydispersity of naturally produced PGGA without disturbing the chemical constitution of the polymer. Copyright 1999 John Wiley & Sons, Inc.

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Year:  1999        PMID: 10099586

Source DB:  PubMed          Journal:  Biotechnol Bioeng        ISSN: 0006-3592            Impact factor:   4.530


  7 in total

1.  Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines.

Authors:  Benedikt A Aulinger; Michael H Roehrl; John J Mekalanos; R John Collier; Julia Y Wang
Journal:  Infect Immun       Date:  2005-06       Impact factor: 3.441

2.  The Poly-γ-d-Glutamic Acid Capsule Surrogate of the Bacillus anthracis Capsule Is a Novel Toll-Like Receptor 2 Agonist.

Authors:  Jun Ho Jeon; Hae-Ri Lee; Min-Hee Cho; Ok-Kyu Park; Jungchan Park; Gi-eun Rhie
Journal:  Infect Immun       Date:  2015-07-20       Impact factor: 3.441

3.  Enzymatic synthesis of high-molecular-mass poly-gamma-glutamate and regulation of its stereochemistry.

Authors:  Makoto Ashiuchi; Kazuya Shimanouchi; Hisaaki Nakamura; Tohru Kamei; Kenji Soda; Chung Park; Moon-Hee Sung; Haruo Misono
Journal:  Appl Environ Microbiol       Date:  2004-07       Impact factor: 4.792

4.  A dually active anthrax vaccine that confers protection against both bacilli and toxins.

Authors:  Gi-Eun Rhie; Michael H Roehrl; Michael Mourez; R John Collier; John J Mekalanos; Julia Y Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-05       Impact factor: 11.205

Review 5.  Microbial production and chemical transformation of poly-γ-glutamate.

Authors:  Makoto Ashiuchi
Journal:  Microb Biotechnol       Date:  2013-07-15       Impact factor: 5.813

Review 6.  Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications.

Authors:  Ibrahim R Khalil; Alan T H Burns; Iza Radecka; Marek Kowalczuk; Tamara Khalaf; Grazyna Adamus; Brian Johnston; Martin P Khechara
Journal:  Int J Mol Sci       Date:  2017-02-02       Impact factor: 5.923

Review 7.  Microbial synthesis of poly-γ-glutamic acid: current progress, challenges, and future perspectives.

Authors:  Zhiting Luo; Yuan Guo; Jidong Liu; Hua Qiu; Mouming Zhao; Wei Zou; Shubo Li
Journal:  Biotechnol Biofuels       Date:  2016-06-29       Impact factor: 6.040

  7 in total

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