The role of radiosurgery for glial neoplasms.

Malignant gliomas are one of the most serious challenges in clinical neurosurgery. Despite advances in surgical and radiation techniques, chemotherapy, and other systemic antineoplastic regimens, such as gene therapy and immunotherapy, patients who suffer from malignant gliomas often succumb to their disease. Although some success has been made with forms of enhanced surgical guidance and localized radiotherapy, current techniques are unable to eradicate the infiltrative glioma cells.