Literature DB >> 10098674

Synthesis of a tetrasubstituted bicyclo [2.2.2] octane as a potential inhibitor of influenza virus sialidase.

P W Smith1, N Trivedi, P D Howes, S L Sollis, G Rahim, R C Bethell, S Lynn.   

Abstract

A novel synthesis of the bicyclo [2.2.2] octane ring system has been achieved utilising a tandem Henry cyclisation as the key stage. This chemistry has been employed in the synthesis of a potential inhibitor of influenza virus sialidase.

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Year:  1999        PMID: 10098674     DOI: 10.1016/s0960-894x(99)00033-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Synthesis and transformations of di-endo-3-aminobicyclo-[2.2.2]oct-5-ene-2-carboxylic acid derivatives.

Authors:  Márta Palkó; Pál Sohár; Ferenc Fülöp
Journal:  Molecules       Date:  2011-09-07       Impact factor: 4.411

  1 in total

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