| Literature DB >> 10098671 |
M Roe1, A Folkes, P Ashworth, J Brumwell, L Chima, S Hunjan, I Pretswell, W Dangerfield, H Ryder, P Charlton.
Abstract
We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described.Entities:
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Year: 1999 PMID： 10098671 DOI： 10.1016/s0960-894x(99)00030-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823