| Literature DB >> 10098666 |
A T Johnson1, L Wang, S J Gillett, R A Chandraratna.
Abstract
A series of high affinity retinoic acid receptor (RAR) antagonists were prepared based upon the known antagonist AGN 193109 (2). Introduction of various phenyl groups revealed a preference for substitution at the para-position relative to the meta-site. Antagonists with the highest affinities for the RARs possessed hydrophobic groups, however, the presence of polar functionality was also well tolerated.Mesh：
Substances：
Year: 1999 PMID： 10098666 DOI： 10.1016/s0960-894x(99)00047-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823