Literature DB >> 10098665

Syntheses and biological activities of bis(3-indolyl)thiazoles, analogues of marine bis(indole)alkaloid nortopsentins.

X H Gu1, X Z Wan, B Jiang.   

Abstract

The thiazole analogues of the marine bis(indole)alkaloid nortopsentins, 2,4-bis(3-indolyl)thiazoles, were synthesized using Hantzsch reaction between indole-3-thioamides and 3-(alpha-bromoacetyl)indoles as the key step, and these analogues showed potent cytotoxic activities against a variety of human cancer cell lines in vitro.

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Year:  1999        PMID： 10098665     DOI： 10.1016/s0960-894x(99)00037-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Marine alkaloid polycarpine and its synthetic derivative dimethylpolycarpine induce apoptosis in JB6 cells through p53- and caspase 3-dependent pathways.

Authors:  Sergey N Fedorov; Ann M Bode; Valentin A Stonik; Irina A Gorshkova; Patricia C Schmid; Oleg S Radchenko; Evgueni V Berdyshev; Zigang Dong
Journal:  Pharm Res       Date:  2004-12       Impact factor: 4.200

Review 2.  The Molecular Diversity of 1H-Indole-3-Carbaldehyde Derivatives and Their Role in Multicomponent Reactions.

Authors:  Ghodsi Mohammadi Ziarani; Samira Hasani; Fatemeh Mohajer; Rajender S Varma; Fatemeh Rafiee
Journal:  Top Curr Chem (Cham)       Date:  2022-04-25

3.  Crystal structure of rac-(3a'R,9a'R)-3a'-(indol-3-yl)-1',2',3',3a',4',9a'-hexa-hydro-spiro-[cyclo-pentane-1,9'-penta-leno[1,2-b]indole] p-xylene hemisolvate.

Authors:  Wayland E Noland; Matthew A Worth; Andrew K Schneerer; Courtney L Paal; Kenneth J Tritch
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-04-18

Review 4.  The azaindole framework in the design of kinase inhibitors.

Authors:  Jean-Yves Mérour; Frédéric Buron; Karen Plé; Pascal Bonnet; Sylvain Routier
Journal:  Molecules       Date:  2014-11-28       Impact factor: 4.411

5.  Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5'-nucleotidase inhibitors.

Authors:  Sidra Hassan; Pervaiz Ali Channar; Fayaz Ali Larik; Aamer Saeed; Hamid Saeed Shah; Joanna Lecka; Jean Sévigny; Jamshed Iqbal
Journal:  R Soc Open Sci       Date:  2018-09-12       Impact factor: 2.963

Review 6.  Design and Synthesis of Anti-Cancer Chimera Molecules Based on Marine Natural Products.

Authors:  Min Woo Ha; Bo Reum Song; Hye Jin Chung; Seung-Mann Paek
Journal:  Mar Drugs       Date:  2019-08-27       Impact factor: 5.118

7.  Synthesis and antiproliferative activity of 2,5-bis(3'-indolyl)pyrroles, analogues of the marine alkaloid nortopsentin.

Authors:  Anna Carbone; Barbara Parrino; Paola Barraja; Virginia Spanò; Girolamo Cirrincione; Patrizia Diana; Armin Maier; Gerhard Kelter; Heinz-Herbert Fiebig
Journal:  Mar Drugs       Date:  2013-03-01       Impact factor: 5.118

8.  Organosilicon-containing thiazole derivatives as potential lipoxygenase inhibitors and anti-inflammatory agents.

Authors:  Athina Geronikaki; Dimitra Hadjipavlou-Litina; Alla Zablotskaya; Izolda Segal
Journal:  Bioinorg Chem Appl       Date:  2007       Impact factor: 7.778

9.  Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles.

Authors:  Mohammed A Al-Omair; Abdelwahed R Sayed; Magdy M Youssef
Journal:  Molecules       Date:  2018-05-10       Impact factor: 4.411
  9 in total

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