| Literature DB >> 10098657 |
M Nomura1, S Kinoshita, H Satoh, T Maeda, K Murakami, M Tsunoda, H Miyachi, K Awano.
Abstract
A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure-activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluorome thyl)-phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.Entities:
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Year: 1999 PMID： 10098657 DOI： 10.1016/s0960-894x(99)00039-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823