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Literature DB >> 10098326

Direct and indirect recognition: the role of MHC antigens in graft rejection.

Abstract

In graft rejection, T-cell stimulation by donor APCs and self-APCs (presenting peptides of donor origin) has been called 'direct' and 'indirect' recognition, respectively. Here, Dina Gould and Hugh Auchincloss consider the traditional arguments favoring direct recognition and highlight recent findings suggesting the importance of indirect responses, thereby questioning some of our basic concepts of transplantation immunology.

Entities: Gene Species

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Year: 1999 PMID： 10098326 DOI： 10.1016/s0167-5699(98)01394-2

Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699

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Cited

56 in total

1. Intravital microscopy identifies selectins that regulate T cell traffic into allografts.

Authors: Thomas R Jones; Nozomu Shirasugi; Andrew B Adams; Thomas C Pearson; Christian P Larsen
Journal: J Clin Invest Date: 2003-12 Impact factor: 14.808

2. Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: with particular emphasis on donor major histocompatibility complex class II+ cells.

Authors: Toyokazu Okuda; Takashi Ishikawa; Olga Azhipa; Naoya Ichikawa; Anthony J Demetris; Thomas E Starzl; Noriko Murase
Journal: Transplantation Date: 2002-07-15 Impact factor: 4.939

Direct and indirect recognition: the role of MHC antigens in graft rejection.

1. Intravital microscopy identifies selectins that regulate T cell traffic into allografts.

2. Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: with particular emphasis on donor major histocompatibility complex class II+ cells.

Review 3. Immunogenicity and allogenicity: a challenge of stem cell therapy.

4. Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejection.

Review 5. Tolerogenic dendritic cells and their potential applications.

Review 6. Regulatory T cells in graft-versus-host disease.

Review 7. Regulatory T-cell therapy in transplantation: moving to the clinic.

Review 8. Immune problems in central nervous system cell therapy.

9. Alloreactive CD8 T cell tolerance requires recipient B cells, dendritic cells, and MHC class II.

Review 10. The role of exosomes in allograft immunity.