Literature DB >> 10098276

Genetic optimization of recombinant glycoprotein production by mammalian cells.

M Fussenegger1, J E Bailey, H Hauser, P P Mueller.   

Abstract

Genetically modified mammalian cells are the preferred system for the production of recombinant therapeutic glycoproteins. Other applications include engineering of cell lines for drug screening and cell-based therapies, and the construction of recombinant viruses for gene therapy. This article highlights contemporary core genetic technologies and emerging strategies for genetically engineering mammalian cells for optimal recombinant-protein expression.

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Year:  1999        PMID： 10098276     DOI： 10.1016/s0167-7799(98)01248-7

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  12 in total

1.  Application of a reversible immortalization system for the generation of proliferation-controlled cell lines.

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Review 3.  Iron and iron-based alloys for temporary cardiovascular applications.

Authors:  A Francis; Y Yang; S Virtanen; A R Boccaccini
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Review 5.  Expression vector cassette engineering for recombinant therapeutic production in mammalian cell systems.

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7.  CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells.

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8.  Improvement of reporter activity by IRES-mediated polycistronic reporter system.

Authors:  Hicham Bouabe; Reinhard Fässler; Jürgen Heesemann
Journal:  Nucleic Acids Res       Date:  2008-02-11       Impact factor: 16.971

9.  Advances in Mammalian cell line development technologies for recombinant protein production.

Authors:  Tingfeng Lai; Yuansheng Yang; Say Kong Ng
Journal:  Pharmaceuticals (Basel)       Date:  2013-04-26

10.  Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production.

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Journal:  PLoS One       Date:  2018-08-02       Impact factor: 3.240
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