PROBLEM: The aim of the present study was to identify the role of mast cells and substance P (SP)-containing nerve fibers in human decidua in normal and pathological pregnancies. METHOD OF STUDY: We collected decidua from women undergoing termination of normal pregnancies and from abortions. The presence of mast cells and SP was detected by immunohistochemistry. RESULTS: We observed a sparse distribution of mast cells in the normal pregnancies (36.7 tryptase+ mast cells/mm2 decidua). In the decidua from abortion, we found a dramatic increase in the number of mast cells (448.7 and 469.2 tryptase+ mast cells/mm2 decidua in primary and secondary abortions, respectively). In addition, we observed an increase of SP-positive nerve fibers in the decidua of abortions. CONCLUSIONS: Our data suggest that decidual mast cells may play an important role in the onset of abortion, due to the production of cytokines, such as tumor necrosis factor-alpha.
PROBLEM: The aim of the present study was to identify the role of mast cells and substance P (SP)-containing nerve fibers in human decidua in normal and pathological pregnancies. METHOD OF STUDY: We collected decidua from women undergoing termination of normal pregnancies and from abortions. The presence of mast cells and SP was detected by immunohistochemistry. RESULTS: We observed a sparse distribution of mast cells in the normal pregnancies (36.7 tryptase+ mast cells/mm2 decidua). In the decidua from abortion, we found a dramatic increase in the number of mast cells (448.7 and 469.2 tryptase+ mast cells/mm2 decidua in primary and secondary abortions, respectively). In addition, we observed an increase of SP-positive nerve fibers in the decidua of abortions. CONCLUSIONS: Our data suggest that decidual mast cells may play an important role in the onset of abortion, due to the production of cytokines, such as tumor necrosis factor-alpha.
Authors: Eva Patak; M Luz Candenas; Jocelyn N Pennefather; Sebastian Ziccone; Alison Lilley; Julio D Martín; Carlos Flores; Antonio G Mantecón; Margot E Story; Francisco M Pinto Journal: Br J Pharmacol Date: 2003-06 Impact factor: 8.739
Authors: W Colin Duncan; Julie L V Shaw; Stewart Burgess; Sarah E McDonald; Hilary O D Critchley; Andrew W Horne Journal: PLoS One Date: 2011-08-17 Impact factor: 3.240