Literature DB >> 10096851

Isolation and identification of dihydroartemisinic acid from artemisia annua and its possible role in the biosynthesis of artemisinin

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Abstract

Dihydroartemisinic acid (2) was isolated as a natural product from Artemisia annua in a 66% yield, and its structure was confirmed by 1H and 13C NMR spectroscopy. Compound 2 could be chemically converted to artemisinin (4) under conditions that may also be present in the living plant. The results suggest that the conversion of 2 into 4 in the living plant might be a nonenzymatic conversion.

Entities:  

Year:  1999        PMID： 10096851     DOI： 10.1021/np980370p

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  20 in total

Review 1.  The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao).

Authors:  Geoffrey D Brown
Journal:  Molecules       Date:  2010-10-28       Impact factor: 4.411

2.  Exogenous salicylic acid-mediated modulation of arsenic stress tolerance with enhanced accumulation of secondary metabolites and improved size of glandular trichomes in Artemisia annua L.

Authors:  Anjana Kumari; Neha Pandey; Shashi Pandey-Rai
Journal:  Protoplasma       Date:  2017-06-30       Impact factor: 3.356

3.  Effects of different doses of cadmium on secondary metabolites and gene expression in Artemisia annua L.

Authors:  Liangyun Zhou; Guang Yang; Haifeng Sun; Jinfu Tang; Jian Yang; Yizhan Wang; Thomas Avery Garran; Lanping Guo
Journal:  Front Med       Date:  2017-03-02       Impact factor: 4.592

4.  Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases.

Authors:  Pamela J Weathers; Patrick R Arsenault; Patrick S Covello; Anthony McMickle; Keat H Teoh; Darwin W Reed
Journal:  Phytochem Rev       Date:  2011-06       Impact factor: 5.374

5.  Arsenic-induced changes in morphological, physiological, and biochemical attributes and artemisinin biosynthesis in Artemisia annua, an antimalarial plant.

Authors:  Rashmi Rai; Sarita Pandey; Shashi Pandey Rai
Journal:  Ecotoxicology       Date:  2011-06-28       Impact factor: 2.823

6.  Methyl jasmonate counteracts boron toxicity by preventing oxidative stress and regulating antioxidant enzyme activities and artemisinin biosynthesis in Artemisia annua L.

Authors:  Tariq Aftab; M Masroor A Khan; Mohd Idrees; M Naeem; Nadeem Hashmi
Journal:  Protoplasma       Date:  2010-10-19       Impact factor: 3.356

7.  DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures.

Authors:  Abdul Mannan; Chunzhao Liu; Patrick R Arsenault; Melissa J Towler; Dan R Vail; Argelia Lorence; Pamela J Weathers
Journal:  Plant Cell Rep       Date:  2009-12-20       Impact factor: 4.570

8.  The effect of roots and media constituents on trichomes and artemisinin production in Artemisia annua L.

Authors:  Khanhvan T Nguyen; Melissa J Towler; Pamela J Weathers
Journal:  Plant Cell Rep       Date:  2012-10-20       Impact factor: 4.570

9.  Salicylic acid activates artemisinin biosynthesis in Artemisia annua L.

Authors:  Gao-Bin Pu; Dong-Ming Ma; Jian-Lin Chen; Lan-Qing Ma; Hong Wang; Guo-Feng Li; He-Chun Ye; Ben-Ye Liu
Journal:  Plant Cell Rep       Date:  2009-06-12       Impact factor: 4.570

10.  Differentially expressed genes during contrasting growth stages of Artemisia annua for artemisinin content.

Authors:  Priya Nair; Amita Misra; Alka Singh; Ashutosh K Shukla; Madan M Gupta; Anil K Gupta; Vikrant Gupta; Suman P S Khanuja; Ajit K Shasany
Journal:  PLoS One       Date:  2013-04-03       Impact factor: 3.240
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