Literature DB >> 10096831

A modified HPLC method for the determination of vancomycin in plasma and tissues and comparison to FPIA (TDX).

D Farin1, G A Piva, I Gozlan, R Kitzes-Cohen.   

Abstract

A modified high performance liquid chromatography (HPLC) method for the quantification of vancomycin levels in plasma and tissues is described. The method uses solid phase extraction (SPE) of vancomycin from the samples and reversed phase HPLC with UV detection. The method was fully validated in terms of recovery, linearity, selectivity and various stability conditions. Vancomycin was determined in plasma samples obtained from 15 patients undergoing cardiopulmonary bypass, before and repeatedly during 12 h after drug administration. The vancomycin levels in plasma were measured by HPLC and by fluorescence polarization immunoassay (FPIA) (TDX). The following correlation was found: TDX = 0.84 HPLC + 1.04. The mean vancomycin levels in skin, fat, atrium, pericardium and sternum, before and after bypass, are reported.

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Year:  1998        PMID： 10096831     DOI： 10.1016/s0731-7085(98)00095-8

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  6 in total

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Journal:  ACS Sens       Date:  2019-10-15       Impact factor: 7.711

2.  Penetration of linezolid into rabbit intervertebral discs and surrounding tissues.

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3.  Catalysis of electro-oxidation of antibiotics by nitroxyl radicals and the electrochemical sensing of vancomycin.

Authors:  Tetsuya Ono; Kyoko Sugiyama; Sachiko Komatsu; Masayuki Kumano; Kentaro Yoshida; Takenori Dairaku; Tsutomu Fujimura; Yusuke Sasano; Yoshiharu Iwabuchi; Yoshitomo Kashiwagi; Katsuhiko Sato
Journal:  RSC Adv       Date:  2021-06-18       Impact factor: 3.361

4.  Simultaneous and Direct Determination of Vancomycin and Cephalexin in Human Plasma by Using HPLC-DAD Coupled with Second-Order Calibration Algorithms.

Authors:  Le-Qian Hu; Chun-Ling Yin; Ya-Hui Du; Zhi-Peng Zeng
Journal:  J Anal Methods Chem       Date:  2012-04-22       Impact factor: 2.193

5.  Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates.

Authors:  Christine Dieterich; Angela Puey; Sylvia Lin; Sylvia Lyn; Robert Swezey; Anna Furimsky; David Fairchild; Jon C Mirsalis; Hanna H Ng
Journal:  Toxicol Sci       Date:  2008-10-16       Impact factor: 4.849

6.  Development and validation of an HPLC method for the determination of vancomycin in human plasma and its comparison with an immunoassay (PETINIA).

Authors:  Muhammad Usman; Georg Hempel
Journal:  Springerplus       Date:  2016-02-18
  6 in total

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