OBJECTIVE: To help clinicians more accurately predict outcomes of treatment for depression, variables associated with recurrence of depression in the year after treatment were examined in a group of patients who completed treatment for an index episode of depression. METHODS:Forty-two depressed patients who participated in a double-blind pharmacological treatment study were followed for one year after treatment was discontinued. Length of treatment for the index episode was determined by clinicians and ranged from eight to 76 consecutive weeks. Eighteen patients who had a recurrent episode (43 percent) and 24 patients who did not (57 percent) were compared on sociodemographic and clinical variables, including scores on the Eysenck Personality Questionnaire (EPQ). RESULTS: A combination of three variables predicted recurrence of depression in 90 percent of cases. They were an elevated EPQ score on the neuroticism subscale, a short duration of treatment of the index episode, and a slow onset of response to treatment of the index episode. CONCLUSIONS: The findings suggest that personality traits, treatment duration, and variations in response to treatment might have an impact on long-term treatment outcome. Clinicians should consider these factors when making treatment decisions for depressed patients.
RCT Entities:
OBJECTIVE: To help clinicians more accurately predict outcomes of treatment for depression, variables associated with recurrence of depression in the year after treatment were examined in a group of patients who completed treatment for an index episode of depression. METHODS: Forty-two depressedpatients who participated in a double-blind pharmacological treatment study were followed for one year after treatment was discontinued. Length of treatment for the index episode was determined by clinicians and ranged from eight to 76 consecutive weeks. Eighteen patients who had a recurrent episode (43 percent) and 24 patients who did not (57 percent) were compared on sociodemographic and clinical variables, including scores on the Eysenck Personality Questionnaire (EPQ). RESULTS: A combination of three variables predicted recurrence of depression in 90 percent of cases. They were an elevated EPQ score on the neuroticism subscale, a short duration of treatment of the index episode, and a slow onset of response to treatment of the index episode. CONCLUSIONS: The findings suggest that personality traits, treatment duration, and variations in response to treatment might have an impact on long-term treatment outcome. Clinicians should consider these factors when making treatment decisions for depressedpatients.
Authors: Alexander J Shackman; Do P M Tromp; Melissa D Stockbridge; Claire M Kaplan; Rachael M Tillman; Andrew S Fox Journal: Psychol Bull Date: 2016-10-10 Impact factor: 17.737
Authors: Maria A Oquendo; Jason Turret; Michael F Grunebaum; Ainsley K Burke; Ernest Poh; Ellen Stevenson; J John Mann; Hanga Galfalvy Journal: J Affect Disord Date: 2013-06-02 Impact factor: 4.839
Authors: Andrew S Moriarty; Nicholas Meader; Kym Ie Snell; Richard D Riley; Lewis W Paton; Carolyn A Chew-Graham; Simon Gilbody; Rachel Churchill; Robert S Phillips; Shehzad Ali; Dean McMillan Journal: Cochrane Database Syst Rev Date: 2021-05-06
Authors: Alexander J Shackman; Melissa D Stockbridge; Rachael M Tillman; Claire M Kaplan; Do P M Tromp; Andrew S Fox; Matthias Gamer Journal: J Exp Psychopathol Date: 2016
Authors: Andrew S Moriarty; Lewis W Paton; Kym I E Snell; Richard D Riley; Joshua E J Buckman; Simon Gilbody; Carolyn A Chew-Graham; Shehzad Ali; Stephen Pilling; Nick Meader; Bob Phillips; Peter A Coventry; Jaime Delgadillo; David A Richards; Chris Salisbury; Dean McMillan Journal: Diagn Progn Res Date: 2021-07-02