Literature DB >> 10095095

Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats.

S C Danzer1, R O Price, N T McMullen, N E Rance.   

Abstract

Human menopause is associated with hypertrophy and increased gene expression of neurokinin (NKB) neurons in the infundibular (arcuate) nucleus of the hypothalamus. We have hypothesized that these changes are secondary to gonadal failure. In the present study, we determined that orchidectomy resulted in an increase in the mean profile area and the number of neurons expressing NKB mRNA in the rat arcuate nucleus. No changes were seen when orchidectomy was combined with testosterone or estradiol replacement. These findings support our hypothesis and demonstrate that gonadal steroids modulate NKB neurons in the arcuate nucleus of adult male rats. Copyright 1999 Elsevier Science B.V.

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Year:  1999        PMID： 10095095     DOI： 10.1016/s0169-328x(99)00024-8

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  13 in total

Review 1.  Estradiol Membrane-Initiated Signaling and Female Reproduction.

Authors:  Paul E Micevych; Angela May Wong; Melinda Anne Mittelman-Smith
Journal:  Compr Physiol       Date:  2015-07-01       Impact factor: 9.090

2.  Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids.

Authors:  F Ruiz-Pino; V M Navarro; A H Bentsen; D Garcia-Galiano; M A Sanchez-Garrido; P Ciofi; R A Steiner; J D Mikkelsen; L Pinilla; M Tena-Sempere
Journal:  Endocrinology       Date:  2012-07-20       Impact factor: 4.736

Review 3.  Neurokinin B and the hypothalamic regulation of reproduction.

Authors:  Naomi E Rance; Sally J Krajewski; Melinda A Smith; Marina Cholanian; Penny A Dacks
Journal:  Brain Res       Date:  2010-08-25       Impact factor: 3.252

4.  Limbic Neuropeptidergic Modulators of Emotion and Their Therapeutic Potential for Anxiety and Post-Traumatic Stress Disorder.

Authors:  Paul J Marvar; Raül Andero; Rene Hurlemann; Tiffany R Lago; Moriel Zelikowsky; Joanna Dabrowska
Journal:  J Neurosci       Date:  2021-01-20       Impact factor: 6.167

5.  Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse.

Authors:  Victor M Navarro; Michelle L Gottsch; Charles Chavkin; Hiroaki Okamura; Donald K Clifton; Robert A Steiner
Journal:  J Neurosci       Date:  2009-09-23       Impact factor: 6.167

6.  Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty.

Authors:  Alexander S Kauffman; Víctor M Navarro; Joshua Kim; Donald K Clifton; Robert A Steiner
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-09-15       Impact factor: 4.310

7.  Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback.

Authors:  Naomi E Rance
Journal:  Peptides       Date:  2008-05-28       Impact factor: 3.750

8.  Interactions between kisspeptins and neurokinin B.

Authors:  Víctor M Navarro
Journal:  Adv Exp Med Biol       Date:  2013       Impact factor: 2.622

9.  Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat.

Authors:  S J Krajewski; M C Burke; M J Anderson; N T McMullen; N E Rance
Journal:  Neuroscience       Date:  2009-12-28       Impact factor: 3.590

10.  Beyond Leptin: Emerging Candidates for the Integration of Metabolic and Reproductive Function during Negative Energy Balance.

Authors:  Cadence True; Kevin L Grove; M Susan Smith
Journal:  Front Endocrinol (Lausanne)       Date:  2011-10-17       Impact factor: 5.555
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