Literature DB >> 10091993

Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1.

H Gruffat, S Portes-Sentis, A Sergeant, E Manet.   

Abstract

Analysis of the recently completed genomic sequence of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) revealed that ORF 50 encodes a protein with homology to the Epstein-Barr virus (EBV) transcription factor R. In this report, we show that ORF K8, contiguous to ORF 50, is interrupted by two introns and that the spliced RNA is translated into a bZip protein that has homology to the EBV transcription factor EB1. The newly characterized K8 protein forms homodimers but does not heterodimerize with other members of the bZip protein family.

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Year:  1999        PMID： 10091993     DOI： 10.1099/0022-1317-80-3-557

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  23 in total

Review 1.  Evolutionary aspects of oncogenic herpesviruses.

Authors:  J Nicholas
Journal:  Mol Pathol       Date:  2000-10

2.  Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replication.

Authors:  Iglika V Pavlova; Herbert W Virgin; Samuel H Speck
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

3.  The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity.

Authors:  J Park; T Seo; S Hwang; D Lee; Y Gwack; J Choe
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

4.  Investigation of the multimerization region of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) protein K-bZIP: the proposed leucine zipper region encodes a multimerization domain with an unusual structure.

Authors:  Salama Al Mehairi; Eleanora Cerasoli; Alison J Sinclair
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

5.  De novo protein synthesis is required for lytic cycle reactivation of Epstein-Barr virus, but not Kaposi's sarcoma-associated herpesvirus, in response to histone deacetylase inhibitors and protein kinase C agonists.

Authors:  Jianjiang Ye; Lyndle Gradoville; Derek Daigle; George Miller
Journal:  J Virol       Date:  2007-06-27       Impact factor: 5.103

6.  A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus.

Authors:  Thomas J Ellison; Yoshihiro Izumiya; Chie Izumiya; Paul A Luciw; Hsing-Jien Kung
Journal:  Virology       Date:  2009-03-09       Impact factor: 3.616

7.  Transcription activation of polyadenylated nuclear rna by rta in human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus.

Authors:  M J Song; H J Brown; T T Wu; R Sun
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

8.  Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases.

Authors:  A G Polson; L Huang; D M Lukac; J D Blethrow; D O Morgan; A L Burlingame; D Ganem
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

9.  Kaposi's sarcoma-associated herpesvirus K8beta is derived from a spliced intermediate of K8 pre-mRNA and antagonizes K8alpha (K-bZIP) to induce p21 and p53 and blocks K8alpha-CDK2 interaction.

Authors:  Koji Yamanegi; Shuang Tang; Zhi-Ming Zheng
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

10.  Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification.

Authors:  Yoshihiro Izumiya; Thomas J Ellison; Edward T H Yeh; Jae U Jung; Paul A Luciw; Hsing-Jien Kung
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103
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