Literature DB >> 10091709

Leucine-phenylalanine dipeptide-based N-mesyloxysuccinimides: synthesis of all four stereoisomers and their assay against serine proteases.

A D Abell1, M D Oldham.   

Abstract

The four stereoisomers of 3-(N-acetylleucylamino)-3-benzyl-1-[(methylsulfonyl)oxy]succinimid e have been prepared and shown to inhibit alpha-chymotrypsin and human neutrophil elastase. The structural and stereochemical features that affect the potency and selectivity of inhibition are discussed.

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Year:  1999        PMID： 10091709     DOI： 10.1016/s0960-894x(99)00017-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Lossen Rearrangement of p-Toluenesulfonates of N-Oxyimides in Basic Condition, Theoretical Study, and Molecular Docking.

Authors:  Monika Kijewska; Abeer A Sharfalddin; Łukasz Jaremko; Marta Cal; Bartosz Setner; Miłosz Siczek; Piotr Stefanowicz; Mostafa A Hussien; Abdul-Hamid Emwas; Mariusz Jaremko
Journal:  Front Chem       Date:  2021-04-15       Impact factor: 5.221

2.  One-pot efficient synthesis of N(α)-urethane-protected β- and γ-amino acids.

Authors:  Marta Cal; Mariusz Jaremko; Łukasz Jaremko; Piotr Stefanowicz
Journal:  Amino Acids       Date:  2012-12-19       Impact factor: 3.520
  2 in total

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