Literature DB >> 10091687

Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases.

X Y Yu1, J M Hill, G Yu, W Wang, A F Kluge, P Wendler, P Gallant.   

Abstract

A series of novel aminoacyl adenylate mimics has been prepared and evaluated for their inhibitory activity against aminoacyl-tRNA synthetases. Several of these thiazole derivatives displayed potent and selective enzyme activity against both Gram-positive and Gram-negative bacteria.

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Year:  1999        PMID： 10091687     DOI： 10.1016/s0960-894x(98)00738-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Drug target validation: lethal infection blocked by inducible peptide.

Authors:  J Tao; P Wendler; G Connelly; A Lim; J Zhang; M King; T Li; J A Silverman; P R Schimmel; F P Tally
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

Review 2.  Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents.

Authors:  Panpan Zhang; Shutao Ma
Journal:  Medchemcomm       Date:  2019-05-27       Impact factor: 3.597

3.  Selective inhibition of biotin protein ligase from Staphylococcus aureus.

Authors:  Tatiana P Soares da Costa; William Tieu; Min Y Yap; Nicole R Pendini; Steven W Polyak; Daniel Sejer Pedersen; Renato Morona; John D Turnidge; John C Wallace; Matthew C J Wilce; Grant W Booker; Andrew D Abell
Journal:  J Biol Chem       Date:  2012-03-21       Impact factor: 5.157

4.  Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery.

Authors:  William Tieu; Steven W Polyak; Ashleigh S Paparella; Min Y Yap; Tatiana P Soares da Costa; Belinda Ng; Geqing Wang; Richard Lumb; Jan M Bell; John D Turnidge; Matthew C J Wilce; Grant W Booker; Andrew D Abell
Journal:  ACS Med Chem Lett       Date:  2014-12-11       Impact factor: 4.345

5.  N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.

Authors:  Michael H Charlton; Rihards Aleksis; Adélaïde Saint-Leger; Arya Gupta; Einars Loza; Lluís Ribas de Pouplana; Ilze Kaula; Daina Gustina; Marina Madre; Daina Lola; Kristaps Jaudzems; Grace Edmund; Christopher P Randall; Louise Kime; Alex J O'Neill; Wil Goessens; Aigars Jirgensons; Paul W Finn
Journal:  ACS Med Chem Lett       Date:  2018-01-18       Impact factor: 4.345

6.  Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases.

Authors:  Manesh Nautiyal; Bharat Gadakh; Steff De Graef; Luping Pang; Masroor Khan; Yi Xun; Jef Rozenski; Arthur Van Aerschot
Journal:  Antibiotics (Basel)       Date:  2019-10-09

Review 7.  Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification.

Authors:  Pengfei Fang; Min Guo
Journal:  Life (Basel)       Date:  2015-12-08
  7 in total

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