| Literature DB >> 10091675 |
M H Chen1, M G Steiner, S E de Laszlo, A A Patchett, M S Anderson, S A Hyland, H R Onishi, L L Silver, C R Raetz.
Abstract
A series of carbohydroxamido-oxazolidine inhibitors of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, the enzyme responsible for the second step in lipid A biosynthesis, was identified. The most potent analog L-161,240 showed an IC50 = 30 nM in the DEACET assay and displayed an MIC of 1-3 microg/mL against wild-type E. coli.Entities:
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Year: 1999 PMID： 10091675 DOI： 10.1016/s0960-894x(98)00749-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823