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Literature DB >> 1008995

Isoprenaline-induced changes in regional myocardial perfusion in the pathogenesis of myocardial necrosis.

Abstract

Isoprenaline in a single dose induces impairment in perfusion of the subendocardial myocardium of the rat left ventricle. This defect in perfusion persists for up to 150 min and corresponds in distribution to the myocardial necrosis produced by similar doses of isoprenaline. It is mediated by the beta-receptors as it is prevented by beta-blockade with propranolol. It is considered that isoprenaline-induced myocardial necrosis represents myocardial infarction.

Entities: Chemical Disease Species

Mesh：

Substances：
Isoproterenol

Year: 1976 PMID： 1008995 PMCID： PMC2041247

Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021

31 in total

1. Histochemical study of effects of hypoxia and isoproterenol on rat myocardium.

Authors: N R Niles; J D Zavin; R N Morikado
Journal: Am J Cardiol Date: 1968-09 Impact factor: 2.778

2. Experimental cardiomegalies and "cardiomegalies" in free-living animals.

Authors: O Poupa; B Ostádal
Journal: Ann N Y Acad Sci Date: 1969-01-31 Impact factor: 5.691

3. Capacity of the terminal vascular bed during normal growth, in cardiomegaly, and in cardiac atrophy.

Authors: K Rakusan; W du Mesnil de Rochemont; W Braasch; H Tschopp; R J Bing
Journal: Circ Res Date: 1967-08 Impact factor: 17.367

4. Effects of myocardial strains on coronary blood flow.

Authors: J M Downey; H F Downey; E S Kirk
Journal: Circ Res Date: 1974-03 Impact factor: 17.367

5. Effects of isoproterenol, l-norepinephrine, and glucagon on myocardial gas tensions in animals with coronary artery stenosis.

Authors: A Furuse; R K Brawley; V L Gott
Journal: J Thorac Cardiovasc Surg Date: 1973-05 Impact factor: 5.209

1. Effects of isoprenaline on functional capillary density in the subendocardial and subepicardial layer of the rat myocardium.

Authors: F Vetterlein; G Schmidt
Journal: Basic Res Cardiol Date: 1980 Jul-Aug Impact factor: 17.165

2. Myocardial infarction during asthmatic attack induced by ingestion of propranolol.

Authors: A B Millar
Journal: J R Soc Med Date: 1982-08 Impact factor: 18.000

2 in total

Isoprenaline-induced changes in regional myocardial perfusion in the pathogenesis of myocardial necrosis.

1. Histochemical study of effects of hypoxia and isoproterenol on rat myocardium.

2. Experimental cardiomegalies and "cardiomegalies" in free-living animals.

3. Capacity of the terminal vascular bed during normal growth, in cardiomegaly, and in cardiac atrophy.

4. Effects of myocardial strains on coronary blood flow.

5. Effects of isoproterenol, l-norepinephrine, and glucagon on myocardial gas tensions in animals with coronary artery stenosis.

6. Myocardial cationic shifts induced by isoproterenol. Electron microscopic and electron probe studies.

7. Ischemic contracture of the heart: "stone heart".

8. Acute myocardial histopathology in normal and arteriosclerotic rats during isoproterenol-induced infarction.

9. Quantitation of isoprenaline-induced changes in the ventricular myocardium.

10. Fine structural study of myocardial changes induced by isoproterenol in rhesus monkeys. (Macaca mulatta).

1. Effects of isoprenaline on functional capillary density in the subendocardial and subepicardial layer of the rat myocardium.

2. Myocardial infarction during asthmatic attack induced by ingestion of propranolol.