Literature DB >> 10088728

Differentiation and apoptosis of neuroblastoma cells: role of N-myc gene product.

U Galderisi1, G Di Bernardo, M Cipollaro, G Peluso, A Cascino, R Cotrufo, M A Melone.   

Abstract

To clarify the role and function of the N-myc product in cell differentiation and apoptosis, we used the antisense oligonucleotide technique to inhibit N-myc gene expression in neuroblastoma cells with different phenotypes: intermediate (I) and neuronal (N), or Schwann-glia (S), respectively. The results suggest that N-myc operates along different pathways. Inhibiting N-myc gene expression either results in suppression of cell proliferation or in induction of differentiation and/or apoptosis.

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Year:  1999        PMID： 10088728     DOI： 10.1002/(sici)1097-4644(19990401)73:1<97::aid-jcb11>3.0.co;2-m

Source DB:  PubMed          Journal:  J Cell Biochem        ISSN： 0730-2312            Impact factor:   4.429


  23 in total

1.  Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3.

Authors:  Eric Potvin; Laurent Beuret; Jean-François Cadrin-Girard; Marcelle Carter; Sophie Roy; Michel Tremblay; Jean Charron
Journal:  Mol Cell Biol       Date:  2010-09-20       Impact factor: 4.272

2.  Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells.

Authors:  Nicola Alessio; Wolfgang Bohn; Verena Rauchberger; Flavio Rizzolio; Marilena Cipollaro; Michael Rosemann; Martin Irmler; Johannes Beckers; Antonio Giordano; Umberto Galderisi
Journal:  Cell Mol Life Sci       Date:  2013-01-31       Impact factor: 9.261

3.  MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells.

Authors:  Jung-Hee Kang; Piotr G Rychahou; Titilope A Ishola; Jingbo Qiao; B Mark Evers; Dai H Chung
Journal:  Biochem Biophys Res Commun       Date:  2006-10-12       Impact factor: 3.575

4.  RB2/p130 ectopic gene expression in neuroblastoma stem cells: evidence of cell-fate restriction and induction of differentiation.

Authors:  F P Jori; U Galderisi; E Piegari; G Peluso; M Cipollaro; A Cascino; A Giordano; M A Melone
Journal:  Biochem J       Date:  2001-12-15       Impact factor: 3.857

5.  Silencing of the MYCN gene by siRNA delivered by folate receptor-targeted liposomes in LA-N-5 cells.

Authors:  Chen Feng; Tianyou Wang; Ruihong Tang; Jianwen Wang; Hui Long; Xiaoning Gao; Suoqin Tang
Journal:  Pediatr Surg Int       Date:  2010-08-25       Impact factor: 1.827

6.  TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception.

Authors:  Catia Giordano; Luigia Cristino; Livio Luongo; Dario Siniscalco; Stefania Petrosino; Fabiana Piscitelli; Ida Marabese; Luisa Gatta; Francesca Rossi; Roberta Imperatore; Enza Palazzo; Vito de Novellis; Vincenzo Di Marzo; Sabatino Maione
Journal:  Cereb Cortex       Date:  2011-12-01       Impact factor: 5.357

7.  Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells.

Authors:  P Nahreini; C Andreatta; K N Prasad
Journal:  Cell Mol Neurobiol       Date:  2001-10       Impact factor: 5.046

8.  Complicated mechanisms of class II transactivator transcription deficiency in small cell lung cancer and neuroblastoma.

Authors:  Takuya Yazawa; Takaaki Ito; Hiroshi Kamma; Takehisa Suzuki; Koji Okudela; Hiroyuki Hayashi; Hisashi Horiguchi; Takesaburo Ogata; Hideaki Mitsui; Masaichi Ikeda; Hitoshi Kitamura
Journal:  Am J Pathol       Date:  2002-07       Impact factor: 4.307

9.  The growth-inhibitory Ndrg1 gene is a Myc negative target in human neuroblastomas and other cell types with overexpressed N- or c-myc.

Authors:  Jun Li; Leo Kretzner
Journal:  Mol Cell Biochem       Date:  2003-08       Impact factor: 3.396

10.  MYCN concurrence with SAHA-induced cell death in human neuroblastoma cells.

Authors:  Constanza Cortés; Sara C Kozma; Albert Tauler; Santiago Ambrosio
Journal:  Cell Oncol (Dordr)       Date:  2015-08-26       Impact factor: 6.730
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