Literature DB >> 1008838

Metabolism of daunorubicin by a barbiturate-sensitive aldehyde reductase from rat liver.

A J Turner, P E Hick.   

Abstract

A barbiturate-sensitive aldehyde reductase was purified to homogeneity from rat liver and shown to metabolize the cancer-chemotherapeutic antibiotic daunorubicin. The aldehyde reductase may have important roles in the metabolism of exogeneous drugs as well as the aldehyde derivatives of the biogenic amines.

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Year:  1976        PMID： 1008838      PMCID： PMC1164189          DOI： 10.1042/bj1590819

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  Inhibition of aldehyde reductase by acidic metabolites of the biogenic amines.

Authors:  A J Turner; P E Hick
Journal:  Biochem Pharmacol       Date:  1975-09-15       Impact factor: 5.858

2.  The determination of enzyme inhibitor constants.

Authors:  M DIXON
Journal:  Biochem J       Date:  1953-08       Impact factor: 3.857

Review 3.  Metabolism of aldehydes in brain.

Authors:  K F Tipton; M D Houslay; A J Turner
Journal:  Essays Neurochem Neuropharmacol       Date:  1977

4.  Separation of isozymes of horse liver alcohol dehydrogenase and purification of the enzyme by affinity chromatography on an immobilized AMP-analogue.

Authors:  L Andersson; H Jörnvall; A Akeson; K Mosbach
Journal:  Biochim Biophys Acta       Date:  1974-09-11

5.  Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex.

Authors:  W F Bosron; R L Prairie
Journal:  J Biol Chem       Date:  1972-07-25       Impact factor: 5.157

6.  Adriamycin and daunorubicin disposition in the rabbit.

Authors:  N R Bachur; R C Hildebrand; R S Jaenke
Journal:  J Pharmacol Exp Ther       Date:  1974-11       Impact factor: 4.030

7.  Daunomycin inhibition of DNA and RNA synthesis.

Authors:  A Theologides; J W Yarbro; B J Kennedy
Journal:  Cancer       Date:  1968-01       Impact factor: 6.860

8.  Heterogeneity of NADPH-dependent aldehyde reductase from human and rat brain.

Authors:  M M Ris; J P von Wartburg
Journal:  Eur J Biochem       Date:  1973-08-01

9.  The purification and properties of an NADPH-linked aldehyde reductase from pig brain.

Authors:  A J Turner; K F Tipton
Journal:  Eur J Biochem       Date:  1972-10

10.  General ligands in affinity chromatography. Cofactor-substrate elution of enzymes bound to the immobilized nucleotides adenosine 5'-monophosphate and nicotinamide-adenine dinucleotide.

Authors:  K Mosbach; H Guilford; R Ohlsson; M Scott
Journal:  Biochem J       Date:  1972-05       Impact factor: 3.857
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  3 in total

1.  Purification of the high-Km aldehyde reductase from rat brain and liver and from ox brain.

Authors:  A J Rivett; I L Smith; K F Tipton
Journal:  Biochem J       Date:  1981-08-01       Impact factor: 3.857

2.  Uptake and metabolism of daunorubicin by human myelocytic cells.

Authors:  G Vasanthakumar; N K Ahmed
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

3.  Compositional relatedness of aldehyde reductases from several species.

Authors:  W S Davidson; T G Flynn
Journal:  J Mol Evol       Date:  1979-12       Impact factor: 2.395
  3 in total

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