Literature DB >> 10088130

Virulence factors of Helicobacter pylori: implications for vaccine development.

S Suerbaum1, C Josenhans.   

Abstract

Helicobacter pylori is one of the most common infectious diseases in humans and causes gastritis, peptic ulcer disease and malignant tumours of the stomach. This review discusses how H. pylori can colonize the human stomach, an ecological niche that is protected against all other bacteria. Knowledge about the virulence factors of H. pylori has accumulated rapidly over the last decade. Together with the information contained in the complete H. pylori genome sequence, this knowledge is now being applied in the search for a vaccine against this global pathogen.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10088130     DOI： 10.1016/s1357-4310(98)01390-2

Source DB:  PubMed          Journal:  Mol Med Today        ISSN： 1357-4310


  6 in total

1.  In vivo distribution of Helicobacter felis in the gastric mucus of the mouse: experimental method and results.

Authors:  S Schreiber; M Stüben; C Josenhans; P Scheid; S Suerbaum
Journal:  Infect Immun       Date:  1999-10       Impact factor: 3.441

2.  Increased mucosal production of monomeric IgA1 but no IgA1 protease activity in Helicobacter pylori gastritis.

Authors:  A E Berstad; M Kilian; K N Valnes; P Brandtzaeg
Journal:  Am J Pathol       Date:  1999-10       Impact factor: 4.307

3.  Colonization of C57BL/6J and BALB/c wild-type and knockout mice with Helicobacter pylori: effect of vaccination and implications for innate and acquired immunity.

Authors:  Klaus Panthel; Gerhard Faller; Rainer Haas
Journal:  Infect Immun       Date:  2003-02       Impact factor: 3.441

4.  The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.

Authors:  B Satin; G Del Giudice; V Della Bianca; S Dusi; C Laudanna; F Tonello; D Kelleher; R Rappuoli; C Montecucco; F Rossi
Journal:  J Exp Med       Date:  2000-05-01       Impact factor: 14.307

5.  Oral Immunization with a Multivalent Epitope-Based Vaccine, Based on NAP, Urease, HSP60, and HpaA, Provides Therapeutic Effect on H. pylori Infection in Mongolian gerbils.

Authors:  Le Guo; Hua Yang; Feng Tang; Runting Yin; Hongpeng Liu; Xiaojuan Gong; Jun Wei; Ying Zhang; Guangxian Xu; Kunmei Liu
Journal:  Front Cell Infect Microbiol       Date:  2017-08-04       Impact factor: 5.293

6.  Mucosal adjuvant activity of IL-2 presenting spores of bacillus subtilis in a murine model of Helicobacter pylori vaccination.

Authors:  Krzysztof Hinc; Małgorzata Stasiłojć; Iwona Piątek; Grażyna Peszyńska-Sularz; Rachele Isticato; Ezio Ricca; Michał Obuchowski; Adam Iwanicki
Journal:  PLoS One       Date:  2014-04-17       Impact factor: 3.240
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.