Literature DB >> 10088042

Basic concepts in the study of diseases with complex genetics.

M Burmeister1.   

Abstract

Most diseases run in families--this is also true of virtually all psychiatric disorders. Twin and adoption studies have shown that most psychiatric disorders have a genetic component, yet very few genetic factors are known, as is true for most disorders with a complex genetic origin. Here I review, for nongeneticists, some of the basic terminology and concepts used when studying complex genetic diseases, with examples from psychiatric genetics. This review is intended to help in the understanding and critical evaluation of reports on genetics of psychiatric illnesses in the literature.

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Year:  1999        PMID： 10088042     DOI： 10.1016/s0006-3223(98)00316-3

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  17 in total

Review 1.  The genetics of panic disorder.

Authors:  C T Finn; J W Smoller
Journal:  Curr Psychiatry Rep       Date:  2001-04       Impact factor: 5.285

Review 2.  Genetic studies of autism: from the 1970s into the millennium.

Authors:  M Rutter
Journal:  J Abnorm Child Psychol       Date:  2000-02

Review 3.  Impact of molecular medicine on neuropsychiatry: the clinician's perspective.

Authors:  J M Ryan; R Loy; P N Tariot
Journal:  Curr Psychiatry Rep       Date:  2001-10       Impact factor: 5.285

Review 4.  Psychogenomics: opportunities for understanding addiction.

Authors:  E J Nestler
Journal:  J Neurosci       Date:  2001-11-01       Impact factor: 6.167

Review 5.  Depression research: where are we now?

Authors:  Saebom Lee; Jaehoon Jeong; Yongdo Kwak; Sang Ki Park
Journal:  Mol Brain       Date:  2010-03-10       Impact factor: 4.041

Review 6.  Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism.

Authors:  Lara A Ray; James Mackillop; Peter M Monti
Journal:  Subst Use Misuse       Date:  2010-09       Impact factor: 2.164

Review 7.  Molecular Mechanisms Underlying the Anti-depressant Effects of Resveratrol: a Review.

Authors:  Marcos Roberto de Oliveira; Aline Lukasievicz Chenet; Adriane Ribeiro Duarte; Giselli Scaini; João Quevedo
Journal:  Mol Neurobiol       Date:  2017-07-10       Impact factor: 5.590

Review 8.  The role of BDNF in depression on the basis of its location in the neural circuitry.

Authors:  Hui Yu; Zhe-yu Chen
Journal:  Acta Pharmacol Sin       Date:  2010-12-06       Impact factor: 6.150

9.  Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.

Authors:  Stuart Macgregor; Penelope A Lind; Kathleen K Bucholz; Narelle K Hansell; Pamela A F Madden; Melinda M Richter; Grant W Montgomery; Nicholas G Martin; Andrew C Heath; John B Whitfield
Journal:  Hum Mol Genet       Date:  2008-11-07       Impact factor: 6.150

10.  AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans.

Authors:  Serina A Neumann; Whittemore G Tingley; Bruce R Conklin; Catherine J Shrader; Eloise Peet; Matthew F Muldoon; J Richard Jennings; Robert E Ferrell; Stephen B Manuck
Journal:  Psychophysiology       Date:  2009-05       Impact factor: 4.016
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