| Literature DB >> 10087947 |
R Morgan1, Z Chen, K Richkind, S Roherty, J Velasco, A A Sandberg.
Abstract
This study documents the utility of a mitogen/cytokine cocktail composed of phytohemagglutinin and Interleukin 2 (PHA/IL2) used to stimulate cultures from patients with chronic lymphoproliferative disorders. We report the results of a selected series of 57 patients with non-Hodgkin lymphoma (NHL) or chronic lymphocytic leukemia (CLL), in which only the culture stimulated with PHA/IL2 demonstrated the presence of an abnormal clone. On average, cells in the abnormal clone comprised 40% of the mitotic cells in this culture. The most common abnormalities observed in these patients were trisomy 12, present in 39% of the cases, and t(14;18), seen in 14% of cases.Entities:
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Year: 1999 PMID： 10087947 DOI： 10.1016/s0165-4608(98)00150-2
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608